benzyl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-aminopentanoate hydrochloride

Base Information

• Chemical Name: benzyl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-aminopentanoate hydrochloride
• CAS No.: 1379586-97-6
• Molecular Formula: C₂₇H₂₈N₂O₄*ClH
• Molecular Weight: 480.991

Synonyms:benzyl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-aminopentanoate hydrochloride

Chemical Property of benzyl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-aminopentanoate hydrochloride

Chemical Property:

Purity/Quality:

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Technology Process of benzyl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-aminopentanoate hydrochloride

There total 1 articles about benzyl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-aminopentanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Fmoc-Orn(Boc)-OH (109425-55-0,118476-89-4) + benzyl chloroformate (501-53-1,94274-21-2) → benzyl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-aminopentanoate hydrochloride (1379586-97-6)

Guidance literature:

Fmoc-Orn(Boc)-OH; benzyl chloroformate; With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 5.5h; Inert atmosphere;

With hydrogenchloride; In dichloromethane; water; Inert atmosphere;

DOI:10.1021/ja301994d

Reference yield: 81.0%

methyl 2-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)thioureido)propanoate + benzyl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-aminopentanoate hydrochloride (1379586-97-6) → benzyl (2S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-((E)-4-methyl-5-oxo-2-(((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)imino)imidazolidin-1-yl)pentanoate

Guidance literature:

With triethylamine; mercury dichloride; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ja301994d

Reference yield:

pyruvic acid methyl ester (600-22-6) + benzyl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-aminopentanoate hydrochloride (1379586-97-6) → benzyl (2S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-((1-methoxy-1-oxopropan-2-yl)amino)pentanoate (1379587-01-5)

Guidance literature:

With sodium acetate; sodium cyanoborohydride; In isopropyl alcohol; at 20 ℃; Inert atmosphere;

DOI:10.1021/ja301994d

upstream raw materials:

Fmoc-Orn(Boc)-OH

benzyl chloroformate

Downstream raw materials:

methyl (5S,12S,Z)-5-((benzyloxy)carbonyl)-10-(((benzyloxy)carbonyl)imino)-9-(bis(4-methoxyphenyl)methyl)-1-(9H-fluoren-9-yl)-12-methyl-3-oxo-2-oxa-4,9,11-triazatridecan-13-oate

tert-butyl (Z)-3-((4S)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(benzyloxy)-5-oxopentyl)-2-((tert-butoxycarbonyl)imino)-4-methyl-5-oxoimidazolidine-1-carboxylate

benzyl (2S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-((1-methoxy-1-oxopropan-2-yl)amino)pentanoate

benzyl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-((bis(4-methoxyphenyl)methyl)amino)pentanoate

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