Technology Process of N-allyl-N'-methyl-3α-hydroxy-12α-(3,5-dimethylbenzoyl)amino-5β-cholan-24-amide
There total 7 articles about N-allyl-N'-methyl-3α-hydroxy-12α-(3,5-dimethylbenzoyl)amino-5β-cholan-24-amide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3α-hydroxy-12α-N-(3,5-dimethylbenzoyl)amino-5β-cholan-24-oic acid;
With
tributyl-amine; chloroformic acid ethyl ester;
In
1,4-dioxane;
at 10 ℃;
for 0.166667h;
N-methyl-N-allylamine;
In
1,4-dioxane;
at 10 - 20 ℃;
for 3h;
DOI:10.1016/S0957-4166(01)00490-6
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: p-toluenesulphonic acid / H2O / Heating
2.1: 95 percent / K2Cr2O7 / H2O; acetic acid / 20 h / 20 °C
3.1: 94 percent / AcONa; NH2OH*HCl / methanol / 4.5 h / Heating
4.1: H2 / PtO2 / acetic acid / 144 h / 20 °C
4.2: 90 percent / Zn; acetic acid / 12 h / 20 °C
5.1: 92 percent / Et3N / tetrahydrofuran / 4 h / 20 °C
6.1: 97 percent / aq. LiOH / tetrahydrofuran; methanol / 5 h / 20 °C
7.1: tri-n-butyl amine; ethyl chloroformate / dioxane / 0.17 h / 10 °C
7.2: 65 percent / dioxane / 3 h / 10 - 20 °C
With
potassium dichromate; lithium hydroxide; tributyl-amine; hydroxylamine hydrochloride; hydrogen; sodium acetate; chloroformic acid ethyl ester; toluene-4-sulfonic acid; triethylamine;
platinum(IV) oxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; acetic acid;
DOI:10.1016/S0957-4166(01)00490-6
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 95 percent / K2Cr2O7 / H2O; acetic acid / 20 h / 20 °C
2.1: 94 percent / AcONa; NH2OH*HCl / methanol / 4.5 h / Heating
3.1: H2 / PtO2 / acetic acid / 144 h / 20 °C
3.2: 90 percent / Zn; acetic acid / 12 h / 20 °C
4.1: 92 percent / Et3N / tetrahydrofuran / 4 h / 20 °C
5.1: 97 percent / aq. LiOH / tetrahydrofuran; methanol / 5 h / 20 °C
6.1: tri-n-butyl amine; ethyl chloroformate / dioxane / 0.17 h / 10 °C
6.2: 65 percent / dioxane / 3 h / 10 - 20 °C
With
potassium dichromate; lithium hydroxide; tributyl-amine; hydroxylamine hydrochloride; hydrogen; sodium acetate; chloroformic acid ethyl ester; triethylamine;
platinum(IV) oxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; acetic acid;
DOI:10.1016/S0957-4166(01)00490-6
