methanesulfonic acid 1-benzyl-2-tert-butoxycarbonylamino-3-phenyl-propyl ester

Base Information

• Chemical Name: methanesulfonic acid 1-benzyl-2-tert-butoxycarbonylamino-3-phenyl-propyl ester
• CAS No.: 922722-37-0
• Molecular Formula: C₂₂H₂₉NO₅S
• Molecular Weight: 419.542

Synonyms:methanesulfonic acid 1-benzyl-2-tert-butoxycarbonylamino-3-phenyl-propyl ester

Chemical Property of methanesulfonic acid 1-benzyl-2-tert-butoxycarbonylamino-3-phenyl-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methanesulfonic acid 1-benzyl-2-tert-butoxycarbonylamino-3-phenyl-propyl ester

There total 2 articles about methanesulfonic acid 1-benzyl-2-tert-butoxycarbonylamino-3-phenyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(1-benzyl-2-hydroxy-3-phenyl-propyl)-carbamic acid tert-butyl ester (922722-36-9) + methanesulfonyl chloride (124-63-0) → methanesulfonic acid 1-benzyl-2-tert-butoxycarbonylamino-3-phenyl-propyl ester (922722-37-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jm060754+

Reference yield:

(3R)-3-(tert-butyloxycarbonylamino)-1,4-diphenylbutan-2-one (188771-20-2) → methanesulfonic acid 1-benzyl-2-tert-butoxycarbonylamino-3-phenyl-propyl ester (922722-37-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / NaBH₄ / methanol / -22 °C

2: 82 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

With sodium tetrahydroborate; triethylamine; In methanol; dichloromethane;

DOI:10.1021/jm060754+

Reference yield: 66.0%

methanesulfonic acid 1-benzyl-2-tert-butoxycarbonylamino-3-phenyl-propyl ester (922722-37-0) → [(1R,2R)-2-azido-1,2-dibenzylethyl]carbamic acid tert-butyl ester (188771-22-4)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 60 ℃; for 16h;

DOI:10.1021/jm060754+

upstream raw materials:

(1-benzyl-2-hydroxy-3-phenyl-propyl)-carbamic acid tert-butyl ester

methanesulfonyl chloride

(3R)-3-(tert-butyloxycarbonylamino)-1,4-diphenylbutan-2-one

Downstream raw materials:

[(1R,2R)-2-azido-1,2-dibenzylethyl]carbamic acid tert-butyl ester

(3R)-3-(tert-butyloxycarbonylamino)-1,4-diphenylbutan-2-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 922722-37-0 methanesulfonic acid 1-benzyl-2-tert-butoxycarbonylamino-3-phenyl-propyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send