2-[2-[(1-cyclopentyl-4-piperidinyl)oxy]-6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide

Base Information

Chemical Name:2-[2-[(1-cyclopentyl-4-piperidinyl)oxy]-6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide
CAS No.:1192313-15-7
Molecular Formula:C₂₈H₃₃F₄N₅O₃
Molecular Weight:563.595
Hs Code.:

Synonyms:2-[2-[(1-cyclopentyl-4-piperidinyl)oxy]-6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide

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Chemical Property of 2-[2-[(1-cyclopentyl-4-piperidinyl)oxy]-6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide

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Technology Process of 2-[2-[(1-cyclopentyl-4-piperidinyl)oxy]-6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide

There total 8 articles about 2-[2-[(1-cyclopentyl-4-piperidinyl)oxy]-6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₃₁F₄N₅O₃

: 1192313-15-7
2-[2-[(1-cyclopentyl-4-piperidinyl)oxy]-6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide

Guidance literature:: C₂₈H₃₁F₄N₅O₃; With sodium tris(acetoxy)borohydride; In 1,1-dichloroethane; for 0.25h;

With water; sodium hydrogencarbonate; In 1,1-dichloroethane; dichloromethane;

Reference yield:

: C₂₈H₃₃F₄N₅O₄

: 1192313-15-7
2-[2-[(1-cyclopentyl-4-piperidinyl)oxy]-6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / 1,1-dichloroethane / 0.25 h

2: sodium tris(acetoxy)borohydride / 1,1-dichloroethane / 0.25 h

With sodium tris(acetoxy)borohydride; acetic acid; In 1,1-dichloroethane;

Reference yield:

: 537050-14-9
2-bromo-1-(4-fluoro-3-(trifluoromethyl)phenyl)ethan-1-one

: 1192313-15-7
2-[2-[(1-cyclopentyl-4-piperidinyl)oxy]-6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: ammonium acetate; acetic acid / 24 h / 130 °C

3.1: dichloromethane / 2 h

4.1: sodium hydride / 1,2-dimethoxyethane; N,N-dimethyl-formamide / 20 °C / Inert atmosphere of nitrogen

4.2: 0.08 h / 0 - 70 °C

5.1: trifluoroacetic acid / dichloromethane / 1 h

6.1: 1,1-dichloroethane / 0.17 h / 20 °C

7.1: acetic acid / 1,1-dichloroethane / 0.25 h

8.1: sodium tris(acetoxy)borohydride / 1,1-dichloroethane / 0.25 h

With ammonium acetate; sodium tris(acetoxy)borohydride; sodium hydride; sodium carbonate; acetic acid; trifluoroacetic acid; In 1,2-dimethoxyethane; 1,1-dichloroethane; dichloromethane; N,N-dimethyl-formamide;