1,1-dimethylethyl 4-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl}oxy)-1-piperidinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl 4-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl}oxy)-1-piperidinecarboxylate
CAS No.:1192313-87-3
Molecular Formula:C₂₃H₂₄F₄N₄O₄
Molecular Weight:496.462
Hs Code.:

Synonyms:1,1-dimethylethyl 4-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl}oxy)-1-piperidinecarboxylate

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Chemical Property of 1,1-dimethylethyl 4-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl}oxy)-1-piperidinecarboxylate

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Technology Process of 1,1-dimethylethyl 4-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl}oxy)-1-piperidinecarboxylate

There total 4 articles about 1,1-dimethylethyl 4-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl}oxy)-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: C₁₈H₁₆F₄N₄O₂

: 1192313-87-3
1,1-dimethylethyl 4-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl}oxy)-1-piperidinecarboxylate

Guidance literature:: In dichloromethane; for 2h;

Reference yield:

: 537050-14-9
2-bromo-1-(4-fluoro-3-(trifluoromethyl)phenyl)ethan-1-one

: 1192313-87-3
1,1-dimethylethyl 4-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl}oxy)-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / N,N-dimethyl-formamide / 20 °C

2: ammonium acetate; acetic acid / 24 h / 130 °C

3: dichloromethane / 2 h

With ammonium acetate; sodium carbonate; acetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1192313-87-3
1,1-dimethylethyl 4-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl}oxy)-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 5,15,10,20-tetraphenylporphyrin; di-tert-butyl (E)-azodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere of nitrogen

2: sodium carbonate / N,N-dimethyl-formamide / 20 °C

3: ammonium acetate; acetic acid / 24 h / 130 °C

4: dichloromethane / 2 h

With ammonium acetate; 5,15,10,20-tetraphenylporphyrin; sodium carbonate; acetic acid; di-tert-butyl (E)-azodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;