tert-butyl-3-((2-methoxy-2-oxoethyl)(methyl)carbamoyl)-2-phenyl-1H-indole-1-carboxylate

Base Information

Chemical Name:tert-butyl-3-((2-methoxy-2-oxoethyl)(methyl)carbamoyl)-2-phenyl-1H-indole-1-carboxylate
CAS No.:1428443-75-7
Molecular Formula:C₂₄H₂₆N₂O₅
Molecular Weight:422.481
Hs Code.:

Synonyms:tert-butyl-3-((2-methoxy-2-oxoethyl)(methyl)carbamoyl)-2-phenyl-1H-indole-1-carboxylate

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Chemical Property of tert-butyl-3-((2-methoxy-2-oxoethyl)(methyl)carbamoyl)-2-phenyl-1H-indole-1-carboxylate

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Technology Process of tert-butyl-3-((2-methoxy-2-oxoethyl)(methyl)carbamoyl)-2-phenyl-1H-indole-1-carboxylate

There total 5 articles about tert-butyl-3-((2-methoxy-2-oxoethyl)(methyl)carbamoyl)-2-phenyl-1H-indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1428443-74-6
1-(tert-butoxycarbonyl)-2-phenyl-1H-indole-3-carboxylic acid

: 13515-93-0
N-methylglycine methyl ester hydrochloride

: 1428443-75-7
tert-butyl-3-((2-methoxy-2-oxoethyl)(methyl)carbamoyl)-2-phenyl-1H-indole-1-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 21.5h; Inert atmosphere;
DOI:10.1039/c2ra21902f

Reference yield: 81.0%

: 1172356-50-1
2-(methylamino)-1-morpholinoethanone hydrochloride

: 1428443-74-6
1-(tert-butoxycarbonyl)-2-phenyl-1H-indole-3-carboxylic acid

: 1428443-75-7
tert-butyl-3-((2-methoxy-2-oxoethyl)(methyl)carbamoyl)-2-phenyl-1H-indole-1-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 20h; Inert atmosphere;
DOI:10.1039/c2ra21902f

Reference yield:

: 193810-67-2
tert-butyl 3-formyl-2-phenyl-1H-indole-1-carboxylate

: 1428443-75-7
tert-butyl-3-((2-methoxy-2-oxoethyl)(methyl)carbamoyl)-2-phenyl-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium dihydrogenphosphate; aminosulfonic acid; sodium chlorite / tetrahydrofuran; water / 4 h / 0 °C

2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 h / Inert atmosphere

With sodium chlorite; sodium dihydrogenphosphate; aminosulfonic acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1039/c2ra21902f