6-Amino-hexanoic acid (3,3-diphenyl-propyl)-[2-(4-hydroxy-phenyl)-ethyl]-amide

Base Information

Chemical Name:6-Amino-hexanoic acid (3,3-diphenyl-propyl)-[2-(4-hydroxy-phenyl)-ethyl]-amide
CAS No.:1027234-57-6
Molecular Formula:C₂₉H₃₆N₂O₂
Molecular Weight:444.617
Hs Code.:

Synonyms:6-Amino-hexanoic acid (3,3-diphenyl-propyl)-[2-(4-hydroxy-phenyl)-ethyl]-amide

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Chemical Property of 6-Amino-hexanoic acid (3,3-diphenyl-propyl)-[2-(4-hydroxy-phenyl)-ethyl]-amide

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Technology Process of 6-Amino-hexanoic acid (3,3-diphenyl-propyl)-[2-(4-hydroxy-phenyl)-ethyl]-amide

There total 9 articles about 6-Amino-hexanoic acid (3,3-diphenyl-propyl)-[2-(4-hydroxy-phenyl)-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 6-Amino-hexanoic acid (3,3-diphenyl-propyl)-[2-(4-methoxy-phenyl)-ethyl]-amide

: 1027234-57-6
6-Amino-hexanoic acid (3,3-diphenyl-propyl)-[2-(4-hydroxy-phenyl)-ethyl]-amide

Guidance literature:: With hydrogen bromide; In acetic acid; for 1h; Heating;
DOI:10.1002/ardp.19973301104

Reference yield:

: 606-83-7
3,3-Diphenylpropionic acid

: 1027234-57-6
6-Amino-hexanoic acid (3,3-diphenyl-propyl)-[2-(4-hydroxy-phenyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 1) Et₃N, ethyl chloroformate / 1) THF, 0 deg C, 30 min, 2) THF, 0 deg C to r.t.

2: 1) POCl₃, 2) NaBH₄ / 1) r.t., 5 h, 2) glyme, r.t., 12 h

3: Et₃N / tetrahydrofuran

4: 1) N₂H₄*H₂O, 2) 10percent HCl / 1) MeOH, reflux, 1 h, 2) MeOH, reflux, 30 min

5: 69 percent / 48percent aq. HBr / acetic acid / 1 h / Heating

With hydrogenchloride; sodium tetrahydroborate; hydrogen bromide; chloroformic acid ethyl ester; hydrazine hydrate; triethylamine; trichlorophosphate; In tetrahydrofuran; acetic acid;
DOI:10.1002/ardp.19973301104

Reference yield:

: 31968-60-2
6-phthalimidohexanoyl chloride

: 1027234-57-6
6-Amino-hexanoic acid (3,3-diphenyl-propyl)-[2-(4-hydroxy-phenyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran

2: 1) N₂H₄*H₂O, 2) 10percent HCl / 1) MeOH, reflux, 1 h, 2) MeOH, reflux, 30 min

3: 69 percent / 48percent aq. HBr / acetic acid / 1 h / Heating

With hydrogenchloride; hydrogen bromide; hydrazine hydrate; triethylamine; In tetrahydrofuran; acetic acid;
DOI:10.1002/ardp.19973301104