3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzylhydroxy)-O-triisopropylsilylphenol

Base Information

Chemical Name:3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzylhydroxy)-O-triisopropylsilylphenol
CAS No.:328236-45-9
Molecular Formula:C₂₉H₄₆O₄Si
Molecular Weight:486.767
Hs Code.:

Synonyms:3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzylhydroxy)-O-triisopropylsilylphenol

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Chemical Property of 3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzylhydroxy)-O-triisopropylsilylphenol

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Technology Process of 3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzylhydroxy)-O-triisopropylsilylphenol

There total 9 articles about 3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzylhydroxy)-O-triisopropylsilylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 328236-42-6
4-bromo-2-isopropyl phenyl methoxymethyl ether

: 328236-44-8
2,6-dimethyl-4-(triisopropyl-silanyloxy)-benzaldehyde

: 328236-45-9
3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzylhydroxy)-O-triisopropylsilylphenol

Guidance literature:: 4-bromo-2-isopropyl phenyl methoxymethyl ether; With n-butyllithium; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

2,6-dimethyl-4-(triisopropyl-silanyloxy)-benzaldehyde; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm800824d

Reference yield:

: 26307-50-6
4-bromo-2-isopropyl-phenol

: 328236-45-9
3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzylhydroxy)-O-triisopropylsilylphenol

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 20 °C

1.2: 90 percent / dimethylformamide / 0.5 h

2.1: n-BuLi / tetrahydrofuran; pentane / 0.5 h / -78 °C

2.2: 68 percent / tetrahydrofuran; pentane / 7 h / -78 - 20 °C

With n-butyllithium; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; pentane;
DOI:10.1016/S0960-894X(00)00531-X

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 328236-45-9
3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzylhydroxy)-O-triisopropylsilylphenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 81 percent / imidazole / CH₂Cl₂ / 1 h

2.1: n-BuLi / tetrahydrofuran; pentane / 0.5 h / -78 °C

2.2: 70 percent / tetrahydrofuran; pentane / 2.5 h / -78 - 20 °C

3.1: n-BuLi / tetrahydrofuran; pentane / 0.5 h / -78 °C

3.2: 68 percent / tetrahydrofuran; pentane / 7 h / -78 - 20 °C

With 1H-imidazole; n-butyllithium; In tetrahydrofuran; dichloromethane; pentane;
DOI:10.1016/S0960-894X(00)00531-X