1-(1-(4-chloro-3-fluorophenyl)vinyl)-4-(2-((1,3-dimethyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

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Chemical Name:1-(1-(4-chloro-3-fluorophenyl)vinyl)-4-(2-((1,3-dimethyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one
CAS No.:1453848-39-9
Molecular Formula:C₂₂H₁₈ClFN₆O
Molecular Weight:436.876
Hs Code.:

Synonyms:1-(1-(4-chloro-3-fluorophenyl)vinyl)-4-(2-((1,3-dimethyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

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Chemical Property of 1-(1-(4-chloro-3-fluorophenyl)vinyl)-4-(2-((1,3-dimethyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

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Technology Process of 1-(1-(4-chloro-3-fluorophenyl)vinyl)-4-(2-((1,3-dimethyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

There total 10 articles about 1-(1-(4-chloro-3-fluorophenyl)vinyl)-4-(2-((1,3-dimethyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 3524-32-1
5-Amino-1,3-dimethylpyrazole

: 1453851-69-8
(S)-1-(2-((tert-butyldimethylsilyl)oxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)-pyridin-2(1H)-one

: 1453848-39-9
1-(1-(4-chloro-3-fluorophenyl)vinyl)-4-(2-((1,3-dimethyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 - 160 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 5527-95-7
4-chloro-3-fluorobenzaldehyde

: 1453848-39-9
1-(1-(4-chloro-3-fluorophenyl)vinyl)-4-(2-((1,3-dimethyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran / 0 - 20 °C

2.1: AD-mix-β / water; tert-butyl alcohol / 0 - 20 °C

3.1: 1H-imidazole / dichloromethane / 1 h / 0 °C

4.1: triethylamine / dichloromethane / 0.5 h / 0 °C

5.1: potassium hexamethylsilazane / tetrahydrofuran / 0.17 h / 0 °C

5.2: 30 h / 20 °C

6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C

7.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.17 h / 20 - 160 °C / Microwave irradiation

With 1H-imidazole; AD-mix-β; potassium hexamethylsilazane; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol; 1.1: |Wittig Rearrangement;

Reference yield:

: 1263414-46-5
1-chloro-2-fluoro-4-vinylbenzene

: 1453848-39-9
1-(1-(4-chloro-3-fluorophenyl)vinyl)-4-(2-((1,3-dimethyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: AD-mix-β / water; tert-butyl alcohol / 0 - 20 °C

2.1: 1H-imidazole / dichloromethane / 1 h / 0 °C

3.1: triethylamine / dichloromethane / 0.5 h / 0 °C

4.1: potassium hexamethylsilazane / tetrahydrofuran / 0.17 h / 0 °C

4.2: 30 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C

6.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.17 h / 20 - 160 °C / Microwave irradiation

With 1H-imidazole; AD-mix-β; potassium hexamethylsilazane; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;