N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-2-(trifluoromethyl)benzamide

Base Information

Chemical Name:N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-2-(trifluoromethyl)benzamide
CAS No.:1005787-36-9
Molecular Formula:C₂₄H₁₈F₃N₅O₃
Molecular Weight:481.434
Hs Code.:

Synonyms:N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-2-(trifluoromethyl)benzamide

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Chemical Property of N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-2-(trifluoromethyl)benzamide

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Technology Process of N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-2-(trifluoromethyl)benzamide

There total 4 articles about N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-2-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 79-37-8
oxalyl dichloride

: 1005777-50-3
N-[6-(3-aminophenoxy)imidazo[1,2-b]pyridazine-2-yl]cyclopropanecarboxamide

: 433-97-6
2-trifluoromethylbenzoic acid

: 1005787-36-9
N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-2-(trifluoromethyl)benzamide

Guidance literature:: With 1-methyl-pyrrolidin-2-one; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1005787-88-1
N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide

: 1005787-36-9
N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-2-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 150 °C

2: 1-methyl-pyrrolidin-2-one / 2 h / 20 °C

With potassium carbonate; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;
DOI:10.1021/jm300126x

Reference yield:

: 433-97-6
2-trifluoromethylbenzoic acid

: 1005787-36-9
N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-2-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / tetrahydrofuran; N,N-dimethyl-formamide / 1.5 h / 4 - 20 °C

2: 1-methyl-pyrrolidin-2-one / 2 h / 20 °C

With oxalyl dichloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;
DOI:10.1021/jm300126x