4-(4-Fluorophenyl)-2-(1-methylethyl)-5H-indeno[1,2-b]pyridine-3-carboxaldehyde

Base Information

Chemical Name:4-(4-Fluorophenyl)-2-(1-methylethyl)-5H-indeno[1,2-b]pyridine-3-carboxaldehyde
CAS No.:137586-34-6
Molecular Formula:C₂₂H₁₈FNO
Molecular Weight:331.389
Hs Code.:

Synonyms:4-(4-Fluorophenyl)-2-(1-methylethyl)-5H-indeno[1,2-b]pyridine-3-carboxaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-Fluorophenyl)-2-(1-methylethyl)-5H-indeno[1,2-b]pyridine-3-carboxaldehyde

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Technology Process of 4-(4-Fluorophenyl)-2-(1-methylethyl)-5H-indeno[1,2-b]pyridine-3-carboxaldehyde

There total 7 articles about 4-(4-Fluorophenyl)-2-(1-methylethyl)-5H-indeno[1,2-b]pyridine-3-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 79-37-8
oxalyl dichloride

: 135426-28-7
4-(4-Fluorophenyl)-2-(1-methylethyl)-5H-indeno[1,2-b]pyridine-3-methanol

: 137586-34-6
4-(4-Fluorophenyl)-2-(1-methylethyl)-5H-indeno[1,2-b]pyridine-3-carboxaldehyde

Guidance literature:: With triethanolamine; SiO₂; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 135426-28-7
4-(4-Fluorophenyl)-2-(1-methylethyl)-5H-indeno[1,2-b]pyridine-3-methanol

: 137586-34-6
4-(4-Fluorophenyl)-2-(1-methylethyl)-5H-indeno[1,2-b]pyridine-3-carboxaldehyde

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; at -78 ℃; for 0.25h;
DOI:10.1021/jm00113a019

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 137586-34-6
4-(4-Fluorophenyl)-2-(1-methylethyl)-5H-indeno[1,2-b]pyridine-3-carboxaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: piperidine, HOAc / benzene / 22 h / Heating

2: 1.) LiN(TMS)2 / 1.) THF, -78 deg C, 1 h, 2.) THF, 1.5 h

3: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

4: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

5: oxalyl chloride, DMSO / CH₂Cl₂; tetrahydrofuran / 0.25 h / -78 °C

With piperidine; lithium aluminium tetrahydride; copper diacetate; oxalyl dichloride; ammonium acetate; acetic acid; dimethyl sulfoxide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; acetic acid; benzene;
DOI:10.1021/jm00113a019