Technology Process of N-[3-(4-chlorophenyl)-2-isobutoxypropyl]-4-isopropyl-2-nitroaniline
There total 7 articles about N-[3-(4-chlorophenyl)-2-isobutoxypropyl]-4-isopropyl-2-nitroaniline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-isopropyl-2-nitrobenzenamine;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 0 - 20 ℃;
for 0.75h;
1-(3-bromo-2-isobutoxypropyl)-4-chlorobenzene;
In
N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
for 18h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogen; zinc dibromide / palladium 10% on activated carbon / ethyl acetate / 42 h / 20 °C / 760.05 Torr
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
2.2: 4 h / 0 - 20 °C
3.1: triphenylphosphine; bromine / dichloromethane / 24.5 h / 0 - 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 0 - 20 °C
4.2: 18 h / 20 °C
With
lithium aluminium tetrahydride; hydrogen; bromine; sodium hydride; triphenylphosphine; zinc dibromide;
palladium 10% on activated carbon;
In
tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium tert-butylate / tetrahydrofuran / 0 - 20 °C
2.1: hydrogen; zinc dibromide / palladium 10% on activated carbon / ethyl acetate / 42 h / 20 °C / 760.05 Torr
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
3.2: 4 h / 0 - 20 °C
4.1: triphenylphosphine; bromine / dichloromethane / 24.5 h / 0 - 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 0 - 20 °C
5.2: 18 h / 20 °C
With
lithium aluminium tetrahydride; potassium tert-butylate; hydrogen; bromine; sodium hydride; triphenylphosphine; zinc dibromide;
palladium 10% on activated carbon;
In
tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
