Technology Process of N-(3,5-dimethoxyphenyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]propane-1,3-diamine
There total 7 articles about N-(3,5-dimethoxyphenyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]propane-1,3-diamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-(3,5-dimethoxyphenyl)-3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinamine;
With
water; potassium hydroxide;
tetrabutylammomium bromide;
In
water;
at 50 ℃;
for 0.5h;
3-bromopropan-1-amine hydrochloride;
In
water;
at 50 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: trichlorophosphate / 2 h / 100 °C
1.2: Cooling with ice
2.1: sodium carbonate / triphenylphosphine; palladium diacetate / 1,2-dimethoxyethane; water / 4 h / Reflux
3.1: sodium t-butanolate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 90 °C / Inert atmosphere
4.1: potassium hydroxide; water / tetrabutylammomium bromide / water / 0.5 h / 50 °C
4.2: 2 h / 50 °C
With
water; sodium carbonate; potassium hydroxide; sodium t-butanolate; trichlorophosphate;
tetrabutylammomium bromide; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triphenylphosphine;
In
1,4-dioxane; 1,2-dimethoxyethane; water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium carbonate / triphenylphosphine; palladium diacetate / 1,2-dimethoxyethane; water / 4 h / Reflux
2.1: sodium t-butanolate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 90 °C / Inert atmosphere
3.1: potassium hydroxide; water / tetrabutylammomium bromide / water / 0.5 h / 50 °C
3.2: 2 h / 50 °C
With
water; sodium carbonate; potassium hydroxide; sodium t-butanolate;
tetrabutylammomium bromide; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triphenylphosphine;
In
1,4-dioxane; 1,2-dimethoxyethane; water;
