2-chloro-4-hydroxy-3-(5-hydroxytetralin-6-yl)-5-phenyl-7H-thieno[2,3-b]pyridin-6-one potassium salt

Base Information

Chemical Name:2-chloro-4-hydroxy-3-(5-hydroxytetralin-6-yl)-5-phenyl-7H-thieno[2,3-b]pyridin-6-one potassium salt
CAS No.:1523493-78-8
Molecular Formula:C₂₃H₁₇ClNO₃S*K
Molecular Weight:462.01
Hs Code.:

Synonyms:2-chloro-4-hydroxy-3-(5-hydroxytetralin-6-yl)-5-phenyl-7H-thieno[2,3-b]pyridin-6-one potassium salt

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Chemical Property of 2-chloro-4-hydroxy-3-(5-hydroxytetralin-6-yl)-5-phenyl-7H-thieno[2,3-b]pyridin-6-one potassium salt

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Technology Process of 2-chloro-4-hydroxy-3-(5-hydroxytetralin-6-yl)-5-phenyl-7H-thieno[2,3-b]pyridin-6-one potassium salt

There total 9 articles about 2-chloro-4-hydroxy-3-(5-hydroxytetralin-6-yl)-5-phenyl-7H-thieno[2,3-b]pyridin-6-one potassium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 2-chloro-4-hydroxy-3-(5-hydroxytetralin-6-yl)-5-phenyl-7H-thieno[2,3-b]pyridin-6-one

: 1523493-78-8
2-chloro-4-hydroxy-3-(5-hydroxytetralin-6-yl)-5-phenyl-7H-thieno[2,3-b]pyridin-6-one potassium salt

Guidance literature:: With potassium carbonate; In acetic acid butyl ester; water; at 100 ℃; for 0.583333h; Solvent; Reagent/catalyst;

Reference yield: 80.0%

: 3-(5-benzyloxytetralin-6-yl)-2-chloro-4-hydroxy-5-phenyl-7H-thieno[2.3-b]pyridin-6-one

: 1523493-78-8
2-chloro-4-hydroxy-3-(5-hydroxytetralin-6-yl)-5-phenyl-7H-thieno[2,3-b]pyridin-6-one potassium salt

Guidance literature:: 3-(5-benzyloxytetralin-6-yl)-2-chloro-4-hydroxy-5-phenyl-7H-thieno[2.3-b]pyridin-6-one; With boron trichloride; In dichloromethane; at -15 - 20 ℃; for 15h;

With potassium carbonate; In water; isopropyl alcohol; at 50 ℃; for 3h; pH=Ca. 12;

Reference yield:

: 95517-07-0
1-(1-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl)ethan-1-one

: 1523493-78-8
2-chloro-4-hydroxy-3-(5-hydroxytetralin-6-yl)-5-phenyl-7H-thieno[2,3-b]pyridin-6-one potassium salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / acetonitrile / 48 h / 76 °C

2.1: acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane / 24 h / 65 °C

2.2: 3 h / Reflux

2.3: 20 °C

3.1: N-chloro-succinimide / dichloromethane / 1 h / Cooling with ice

3.2: 3 h / 0 - 20 °C

4.1: potassium tert-butylate / 2-methyltetrahydrofuran / -16 - 20 °C

5.1: boron trichloride / dichloromethane / 15 h / -15 - 20 °C

6.1: potassium carbonate / acetic acid butyl ester; water / 0.58 h / 100 °C

With N-chloro-succinimide; potassium tert-butylate; boron trichloride; potassium carbonate; acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane; In 2-methyltetrahydrofuran; dichloromethane; acetic acid butyl ester; water; acetonitrile;