N-methyl-N-<(5-methyl-2-phenyl-4-oxazolyl)methyl>-4<(2,4-dioxothiazolidin-5-yl)methyl>benzenesulfonamide

Base Information

• Chemical Name: N-methyl-N-<(5-methyl-2-phenyl-4-oxazolyl)methyl>-4<(2,4-dioxothiazolidin-5-yl)methyl>benzenesulfonamide
• CAS No.: 132451-15-1
• Molecular Formula: C₂₂H₂₁N₃O₅S₂
• Molecular Weight: 471.558
• Mol file: 132451-15-1.mol

Synonyms:N-methyl-N-<(5-methyl-2-phenyl-4-oxazolyl)methyl>-4<(2,4-dioxothiazolidin-5-yl)methyl>benzenesulfonamide

Chemical Property of N-methyl-N-<(5-methyl-2-phenyl-4-oxazolyl)methyl>-4<(2,4-dioxothiazolidin-5-yl)methyl>benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methyl-N-<(5-methyl-2-phenyl-4-oxazolyl)methyl>-4<(2,4-dioxothiazolidin-5-yl)methyl>benzenesulfonamide

There total 9 articles about N-methyl-N-<(5-methyl-2-phenyl-4-oxazolyl)methyl>-4<(2,4-dioxothiazolidin-5-yl)methyl>benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

N-methyl-N-[(5-methyl-2-phenyl-4-oxazolyl)-methyl]amine (132451-29-7) + 4-<(2,4-dioxothiazolidin-5-yl)methyl>benzenesulfonyl chloride (125758-75-0) → N-methyl-N-<(5-methyl-2-phenyl-4-oxazolyl)methyl>-4<(2,4-dioxothiazolidin-5-yl)methyl>benzenesulfonamide (132451-15-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.25h;

DOI:10.1021/jm00088a022

Reference yield:

N-methyl-N-[(5-methyl-2-phenyl-4-oxazolyl)-methyl]amine (132451-29-7) → N-methyl-N-<(5-methyl-2-phenyl-4-oxazolyl)methyl>-4<(2,4-dioxothiazolidin-5-yl)methyl>benzenesulfonamide (132451-15-1)

Guidance literature:

With NaOCH₃; In methanol; chloroform;

Reference yield:

5-benzylidene-2,4-thiazolidinedione (3774-99-0) → N-methyl-N-<(5-methyl-2-phenyl-4-oxazolyl)methyl>-4<(2,4-dioxothiazolidin-5-yl)methyl>benzenesulfonamide (132451-15-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 60 percent / H₂ / 10 percent Pd/C / tetrahydrofuran; acetic acid

2: chlorosulfonic acid / 0.5 h / Ambient temperature

3: 50 percent / diisopropylethylamine / CH₂Cl₂ / 0.25 h / 0 °C

With chlorosulfonic acid; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetic acid;

DOI:10.1021/jm00088a022

upstream raw materials:

N-methyl-N-[(5-methyl-2-phenyl-4-oxazolyl)-methyl]amine

4-<(2,4-dioxothiazolidin-5-yl)methyl>benzenesulfonyl chloride

[5-methyl-2-phenyl-1,3-oxazol-4-yl]methanol

5-(Benzyl)thiazolidine-2,4-dione