4-(1-Methoxycarbonyl-2-nitro-ethyl)-1-methyl-3,5-dioxo-cyclohexanecarboxylic acid tert-butyl ester

Base Information

Chemical Name:4-(1-Methoxycarbonyl-2-nitro-ethyl)-1-methyl-3,5-dioxo-cyclohexanecarboxylic acid tert-butyl ester
CAS No.:191924-67-1
Molecular Formula:C₁₆H₂₃NO₈
Molecular Weight:357.361
Hs Code.:

Synonyms:4-(1-Methoxycarbonyl-2-nitro-ethyl)-1-methyl-3,5-dioxo-cyclohexanecarboxylic acid tert-butyl ester

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Chemical Property of 4-(1-Methoxycarbonyl-2-nitro-ethyl)-1-methyl-3,5-dioxo-cyclohexanecarboxylic acid tert-butyl ester

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Technology Process of 4-(1-Methoxycarbonyl-2-nitro-ethyl)-1-methyl-3,5-dioxo-cyclohexanecarboxylic acid tert-butyl ester

There total 3 articles about 4-(1-Methoxycarbonyl-2-nitro-ethyl)-1-methyl-3,5-dioxo-cyclohexanecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 4749-37-5
3-nitroacrylic acid methyl ester

: 191924-66-0
1-Methyl-3,5-dioxo-cyclohexanecarboxylic acid tert-butyl ester

: 191924-67-1
4-(1-Methoxycarbonyl-2-nitro-ethyl)-1-methyl-3,5-dioxo-cyclohexanecarboxylic acid tert-butyl ester

Guidance literature:: With triethylamine; In methanol; 1.) 0 deg C, 2 h, 2.) room temp., 24 h;
DOI:10.1021/ja964231a

Reference yield:

: 191924-73-9
3,5-Dimethoxy-1-methyl-cyclohexa-2,5-dienecarboxylic acid tert-butyl ester

: 191924-67-1
4-(1-Methoxycarbonyl-2-nitro-ethyl)-1-methyl-3,5-dioxo-cyclohexanecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / Hg(NO₃)2 / acetonitrile; H₂O / 12 h / Heating

2: 99 percent / Et₃N / methanol / 1.) 0 deg C, 2 h, 2.) room temp., 24 h

With mercury(II) nitrate; triethylamine; In methanol; water; acetonitrile;
DOI:10.1021/ja964231a

Reference yield:

: tert-butyl 3,5-dimethoxybenzoate

: 191924-67-1
4-(1-Methoxycarbonyl-2-nitro-ethyl)-1-methyl-3,5-dioxo-cyclohexanecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / NH₃, K / 2-methyl-propan-2-ol; tetrahydrofuran / 2 h / -78 °C

2: 86 percent / Hg(NO₃)2 / acetonitrile; H₂O / 12 h / Heating

3: 99 percent / Et₃N / methanol / 1.) 0 deg C, 2 h, 2.) room temp., 24 h

With ammonia; mercury(II) nitrate; triethylamine; In tetrahydrofuran; methanol; water; acetonitrile; tert-butyl alcohol;
DOI:10.1021/ja964231a