Ethyl 5-Methyl-2-propyl-3H-imidazole-4-carboxylate

Base Information

Chemical Name:Ethyl 5-Methyl-2-propyl-3H-imidazole-4-carboxylate
CAS No.:146650-89-7
Molecular Formula:C₁₀H₁₆N₂O₂
Molecular Weight:196.249
Hs Code.:
DSSTox Substance ID:DTXSID501229773
Nikkaji Number:J2.232.820D

Synonyms:Ethyl 4-methyl-2-propyl-1H-imidazole-5-carboxylate;Ethyl 5-Methyl-2-propyl-3H-imidazole-4-carboxylate;146650-89-7;SCHEMBL5809049;VYIKAKORBYUQBC-UHFFFAOYSA-N;DTXSID501229773;AKOS006324812;2-Propyl-5-methyl-3H-imidazole-4-carboxylic acid ethyl ester

Suppliers and Price of Ethyl 5-Methyl-2-propyl-3H-imidazole-4-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 5-Methyl-2-propyl-3H-imidazole-4-carboxylate

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:196.121177757
Heavy Atom Count:14
Complexity:197

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCCC1=NC(=C(N1)C)C(=O)OCC

Technology Process of Ethyl 5-Methyl-2-propyl-3H-imidazole-4-carboxylate

There total 1 articles about Ethyl 5-Methyl-2-propyl-3H-imidazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 2208-08-4
ethyl butyrimidate hydrochloride

: 20207-16-3
ethyl 2-amino-3-oxobutanoate hydrochloride

: 554-68-7
triethylamine hydrochloride

: 146650-89-7
ethyl 5-methyl-2-propyl-3H-imidazole-4-carboxylate

Guidance literature:: With triethylamine; In ethanol; for 1h;

Reference yield: 53.0%

: 146650-89-7
ethyl 5-methyl-2-propyl-3H-imidazole-4-carboxylate

: 865444-88-8
5-methyl-2-propyl-3H-imidazole-4-carboxamide

Guidance literature:: With ammonium hydroxide; at 130 ℃; for 24h;
DOI:10.1021/jo051014w

Reference yield:

: 146650-89-7
ethyl 5-methyl-2-propyl-3H-imidazole-4-carboxylate

: 224789-21-3
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 53 percent / ammonium hydroxide / 24 h / 130 °C

2.1: lithium hexamethyldisilazane / dimethylformamide; tetrahydrofuran / 0.17 h / -10 °C

2.2: 41 percent / Ph₂P(O)ONH₂ / tetrahydrofuran; dimethylformamide / 20 °C

3.1: 52 percent / pyridine / 2 h / 60 °C

4.1: 72 percent / KOtBu / 2-methyl-propan-2-ol / 30 h / 160 °C

With pyridine; ammonium hydroxide; potassium tert-butylate; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jo051014w