1-(2-chloroacetyl)-5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indoline

Base Information

• Chemical Name: 1-(2-chloroacetyl)-5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indoline
• CAS No.: 957204-54-5
• Molecular Formula: C₂₂H₁₇ClF₃NO₂S
• Molecular Weight: 451.897

Synonyms:1-(2-chloroacetyl)-5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indoline

Chemical Property of 1-(2-chloroacetyl)-5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-chloroacetyl)-5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indoline

There total 1 articles about 1-(2-chloroacetyl)-5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indoline hydrochloride (957203-93-9) + chloroacetyl chloride (79-04-9) → 1-(2-chloroacetyl)-5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indoline (957204-54-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

1-(2-chloroacetyl)-5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indoline (957204-54-5) + glycine ethyl ester hydrochloride (623-33-6) → 2-[N-[2-Oxo-2-[5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indolin-1-yl]ethyl]amino]acetic acid ethyl ester (957204-55-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 - 70 ℃; for 14h;

Reference yield:

1-(2-chloroacetyl)-5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indoline (957204-54-5) + (S)-methyl piperidine-3-carboxylate (276248-50-1) → 1-[2-oxo-2-[5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indolin-1-yl]ethyl]piperidine-(3S)-carboxylic acid methyl ester (957207-94-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 - 80 ℃; for 0.5h;

upstream raw materials:

5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indoline hydrochloride

chloroacetyl chloride

Downstream raw materials:

2-[N-[2-Oxo-2-[5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indolin-1-yl]ethyl]amino]acetic acid ethyl ester

1-[2-oxo-2-[5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indolin-1-yl]ethyl]piperidine-(3S)-carboxylic acid methyl ester

1-[2-oxo-2-[5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indolin-1-yl]ethyl]piperidine-(3R)-carboxylic acid methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 957204-54-5 1-(2-chloroacetyl)-5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indoline

Send

Send

Metric Ton KG G Pound L ML

Send

Send