Technology Process of 5-(2-bromophenyl)-1-phenylpentane-1,3-diketone
There total 6 articles about 5-(2-bromophenyl)-1-phenylpentane-1,3-diketone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
acetophenone;
With
sodium t-butanolate;
In
tetrahydrofuran; toluene;
at 20 ℃;
for 0.5h;
Inert atmosphere;
3-(2-bromophenyl)propanoic acid,methyl ester;
In
tetrahydrofuran; toluene;
at 20 ℃;
Inert atmosphere;
DOI:10.3762/bjoc.11.99
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine; formic acid / 4 h / 10 - 100 °C
2.1: thionyl chloride / 4 h / 20 °C / Reflux
3.1: sodium t-butanolate / toluene; tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
3.2: 20 °C / Inert atmosphere
With
formic acid; thionyl chloride; triethylamine; sodium t-butanolate;
In
tetrahydrofuran; toluene;
DOI:10.3762/bjoc.11.99
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium tetrahydroborate / acetonitrile; methanol / 3.5 h / 20 °C
2.1: potassium hydroxide; water / 8 h / Reflux
3.1: sulfuric acid / water / 20 h / Reflux
4.1: thionyl chloride / 4 h / 20 °C / Reflux
5.1: sodium t-butanolate / toluene; tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
5.2: 20 °C / Inert atmosphere
With
sodium tetrahydroborate; thionyl chloride; sulfuric acid; water; potassium hydroxide; sodium t-butanolate;
In
tetrahydrofuran; methanol; water; toluene; acetonitrile;
DOI:10.3762/bjoc.11.99
