1-[2'-{4-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]phenyl}-5'-(trifluoromethyl)-2,3'-bipyridin-6-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid trifluoroacetate

Base Information

Chemical Name:1-[2'-{4-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]phenyl}-5'-(trifluoromethyl)-2,3'-bipyridin-6-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid trifluoroacetate
CAS No.:1374339-38-4
Molecular Formula:C₂HF₃O₂*C₂₉H₂₂F₉N₅O₂
Molecular Weight:757.536
Hs Code.:

1-[2'-{4-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]phenyl}-5'-(trifluoromethyl)-2,3'-bipyridin-6-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid trifluoroacetate

Synonyms:1-[2'-{4-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]phenyl}-5'-(trifluoromethyl)-2,3'-bipyridin-6-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid trifluoroacetate

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Chemical Property of 1-[2'-{4-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]phenyl}-5'-(trifluoromethyl)-2,3'-bipyridin-6-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid trifluoroacetate

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Technology Process of 1-[2'-{4-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]phenyl}-5'-(trifluoromethyl)-2,3'-bipyridin-6-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid trifluoroacetate

There total 8 articles about 1-[2'-{4-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]phenyl}-5'-(trifluoromethyl)-2,3'-bipyridin-6-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1128269-63-5
ethyl 1-[2'-fluoro-5'-(trifluoromethyl)-2,3'-bipyridin-6-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

: 1374342-10-5
4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-(2,2,2-trifluoroethyl)piperidine

: 76-05-1
trifluoroacetic acid

: 1374339-38-4
1-[2'-{4-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]phenyl}-5'-(trifluoromethyl)-2,3'-bipyridin-6-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid trifluoroacetate

Guidance literature:: ethyl 1-[2'-fluoro-5'-(trifluoromethyl)-2,3'-bipyridin-6-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate; With sodium methylate; In tetrahydrofuran; at 0 - 4 ℃;

With trimethylsilyl iodide; In chloroform; at 60 ℃; for 2h;

4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-(2,2,2-trifluoroethyl)piperidine; trifluoroacetic acid; Further stages;

Reference yield:

: 1374342-09-2
4-(4-bromophenyl)-1-(2,2,2,-trifluoroethyl)piperidine

: 1374339-38-4
1-[2'-{4-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]phenyl}-5'-(trifluoromethyl)-2,3'-bipyridin-6-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium acetate / 1,4-dioxane / 1.5 h / 95 °C / Inert atmosphere

2.1: sodium methylate / tetrahydrofuran / 0 - 4 °C

2.2: 2 h / 60 °C

With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium methylate; potassium acetate; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 1128269-66-8
2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)pyridine

: 1374339-38-4
1-[2'-{4-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]phenyl}-5'-(trifluoromethyl)-2,3'-bipyridin-6-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; cesium fluoride / acetonitrile; water / 0.75 h / 100 °C / Inert atmosphere

2.1: sodium methylate / tetrahydrofuran / 0 - 4 °C

2.2: 2 h / 60 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium methylate; sodium carbonate; cesium fluoride; In tetrahydrofuran; water; acetonitrile;