4-(4-{[(4-nitrophenoxy)carbonyloxy]methyl}benzoyl)benzyl 13-oxo-17-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-3,6,9-trioxa-12-azaheptadecylcarbamate

Base Information

Chemical Name:4-(4-{[(4-nitrophenoxy)carbonyloxy]methyl}benzoyl)benzyl 13-oxo-17-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-3,6,9-trioxa-12-azaheptadecylcarbamate
CAS No.:1428649-12-0
Molecular Formula:C₄₁H₄₉N₅O₁₃S
Molecular Weight:851.932
Hs Code.:

4-(4-{[(4-nitrophenoxy)carbonyloxy]methyl}benzoyl)benzyl 13-oxo-17-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-3,6,9-trioxa-12-azaheptadecylcarbamate

Synonyms:4-(4-{[(4-nitrophenoxy)carbonyloxy]methyl}benzoyl)benzyl 13-oxo-17-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-3,6,9-trioxa-12-azaheptadecylcarbamate

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Chemical Property of 4-(4-{[(4-nitrophenoxy)carbonyloxy]methyl}benzoyl)benzyl 13-oxo-17-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-3,6,9-trioxa-12-azaheptadecylcarbamate

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Technology Process of 4-(4-{[(4-nitrophenoxy)carbonyloxy]methyl}benzoyl)benzyl 13-oxo-17-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-3,6,9-trioxa-12-azaheptadecylcarbamate

There total 6 articles about 4-(4-{[(4-nitrophenoxy)carbonyloxy]methyl}benzoyl)benzyl 13-oxo-17-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-3,6,9-trioxa-12-azaheptadecylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1428649-11-9
4-[4-(hydroxymethyl)benzoyl]benzyl {13-oxo-17-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-3,6,9-trioxa-12-azaheptadecyl}carbamate

: 7693-46-1
4-Nitrophenyl chloroformate

: 1428649-12-0
4-(4-{[(4-nitrophenoxy)carbonyloxy]methyl}benzoyl)benzyl 13-oxo-17-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-3,6,9-trioxa-12-azaheptadecylcarbamate

Guidance literature:: With pyridine; In dichloromethane; for 1h; Reflux;
DOI:10.1016/j.bmc.2013.01.016

Reference yield:

: 359860-27-8
N-(2-(2-(2-(2-amidoethoxy)ethoxy)ethoxy)ethoxy)biotinamide

: 1428649-12-0
4-(4-{[(4-nitrophenoxy)carbonyloxy]methyl}benzoyl)benzyl 13-oxo-17-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-3,6,9-trioxa-12-azaheptadecylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / N,N-dimethyl-formamide / 20 °C

2: pyridine hydrofluoride / tetrahydrofuran / 0 - 20 °C

3: pyridine / dichloromethane / 1 h / Reflux

With pyridine; pyridine hydrofluoride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.01.016

Reference yield:

: 875770-34-6
N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]biotinamide

: 1428649-12-0
4-(4-{[(4-nitrophenoxy)carbonyloxy]methyl}benzoyl)benzyl 13-oxo-17-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-3,6,9-trioxa-12-azaheptadecylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / water; methanol / 20 °C

2: triethylamine / N,N-dimethyl-formamide / 20 °C

3: pyridine hydrofluoride / tetrahydrofuran / 0 - 20 °C

4: pyridine / dichloromethane / 1 h / Reflux

With pyridine; pyridine hydrofluoride; palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.01.016