di-tert-butyl(4-(benzyloxy)pyridine-2,6-diyl)bis(tert-butoxycarbonylcarbamate)

Base Information

• Chemical Name: di-tert-butyl(4-(benzyloxy)pyridine-2,6-diyl)bis(tert-butoxycarbonylcarbamate)
• CAS No.: 350697-61-9
• Molecular Formula: C₃₂H₄₅N₃O₉
• Molecular Weight: 615.724
• Mol file: 350697-61-9.mol

Synonyms:di-tert-butyl(4-(benzyloxy)pyridine-2,6-diyl)bis(tert-butoxycarbonylcarbamate)

Chemical Property of di-tert-butyl(4-(benzyloxy)pyridine-2,6-diyl)bis(tert-butoxycarbonylcarbamate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-tert-butyl(4-(benzyloxy)pyridine-2,6-diyl)bis(tert-butoxycarbonylcarbamate)

There total 3 articles about di-tert-butyl(4-(benzyloxy)pyridine-2,6-diyl)bis(tert-butoxycarbonylcarbamate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

di-tert-butyl dicarbonate (24424-99-5) + 4?benzyloxy?2,6?diaminopyridine (18986-54-4) → di-tert-butyl(4-(benzyloxy)pyridine-2,6-diyl)bis(tert-butoxycarbonylcarbamate) (350697-61-9)

Guidance literature:

With dmap; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1002/1521-3765(20010504)7:9<1889::AID-CHEM1889>3.0.CO;2-7

Reference yield:

dibenzyl 4-(benzyloxy)-2,6-pyridinedicarboxylate (99097-41-3) → di-tert-butyl(4-(benzyloxy)pyridine-2,6-diyl)bis(tert-butoxycarbonylcarbamate) (350697-61-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / NH₃ / methanol / 3 h / 20 °C

2: 76 percent / aq. KOH; Br₂ / 5 h / 90 °C

3: 91 percent / 4-DMAP / CH₂Cl₂ / 24 h / 20 °C

With dmap; potassium hydroxide; ammonia; bromine; In methanol; dichloromethane;

DOI:10.1002/1521-3765(20010504)7:9<1889::AID-CHEM1889>3.0.CO;2-7

Reference yield:

4-benzyloxy-2,6-pyridinedicarboxamide (350697-54-0) → di-tert-butyl(4-(benzyloxy)pyridine-2,6-diyl)bis(tert-butoxycarbonylcarbamate) (350697-61-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / aq. KOH; Br₂ / 5 h / 90 °C

2: 91 percent / 4-DMAP / CH₂Cl₂ / 24 h / 20 °C

With dmap; potassium hydroxide; bromine; In dichloromethane;

DOI:10.1002/1521-3765(20010504)7:9<1889::AID-CHEM1889>3.0.CO;2-7

upstream raw materials:

di-tert-butyl dicarbonate

4?benzyloxy?2,6?diaminopyridine

dibenzyl 4-(benzyloxy)-2,6-pyridinedicarboxylate

4-benzyloxy-2,6-pyridinedicarboxamide

Downstream raw materials:

{1-[6-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-pyridin-2-ylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

4-Benzyloxy-2,6-bis(N-tert-butoxycarbonyl-L-phenylalaninylamino)pyridine

Benzyl 2-{[2,6-bis(N-tert-butoxycarbonyl-L-phenylalanylamino)-4-pyridyl]oxy} acetate

2-{2,6-Bis[N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-4-pyridyloxy} acetic acid