Benzyl 2-{[2,6-bis(bis(N-tert-butoxycarbonyl)amino)]-4-pyridyloxy} acetate

Base Information

• Chemical Name: Benzyl 2-{[2,6-bis(bis(N-tert-butoxycarbonyl)amino)]-4-pyridyloxy} acetate
• CAS No.: 350697-63-1
• Molecular Formula: C₃₄H₄₇N₃O₁₁
• Molecular Weight: 673.761
• Mol file: 350697-63-1.mol

Synonyms:Benzyl 2-{[2,6-bis(bis(N-tert-butoxycarbonyl)amino)]-4-pyridyloxy} acetate

Chemical Property of Benzyl 2-{[2,6-bis(bis(N-tert-butoxycarbonyl)amino)]-4-pyridyloxy} acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzyl 2-{[2,6-bis(bis(N-tert-butoxycarbonyl)amino)]-4-pyridyloxy} acetate

There total 3 articles about Benzyl 2-{[2,6-bis(bis(N-tert-butoxycarbonyl)amino)]-4-pyridyloxy} acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-[6-[bis[(1,1-dimethylethoxy)carbonyl]amino]-1,4-dihydro-4-oxo-2-pyridinyl]-1,3-bis(1,1-dimethylethyl)ester (350697-62-0) + Benzyl bromoacetate (5437-45-6) → Benzyl 2-{[2,6-bis(bis(N-tert-butoxycarbonyl)amino)]-4-pyridyloxy} acetate (350697-63-1)

Guidance literature:

With tetrabutylammomium bromide; potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 18h;

DOI:10.1002/1521-3765(20010504)7:9<1889::AID-CHEM1889>3.0.CO;2-7

Reference yield:

4?benzyloxy?2,6?diaminopyridine (18986-54-4) → Benzyl 2-{[2,6-bis(bis(N-tert-butoxycarbonyl)amino)]-4-pyridyloxy} acetate (350697-63-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / 4-DMAP / CH₂Cl₂ / 24 h / 20 °C

2: 99 percent / H₂ / 10percent Pd/C / ethanol; CH₂Cl₂ / 18 h / 20 °C

3: 99 percent / K₂CO₃; TBAB / dimethylsulfoxide / 18 h / 20 °C

With dmap; tetrabutylammomium bromide; hydrogen; potassium carbonate; 10percent Pd/C; In ethanol; dichloromethane; dimethyl sulfoxide;

DOI:10.1002/1521-3765(20010504)7:9<1889::AID-CHEM1889>3.0.CO;2-7

Reference yield:

di-tert-butyl(4-(benzyloxy)pyridine-2,6-diyl)bis(tert-butoxycarbonylcarbamate) (350697-61-9) → Benzyl 2-{[2,6-bis(bis(N-tert-butoxycarbonyl)amino)]-4-pyridyloxy} acetate (350697-63-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / H₂ / 10percent Pd/C / ethanol; CH₂Cl₂ / 18 h / 20 °C

2: 99 percent / K₂CO₃; TBAB / dimethylsulfoxide / 18 h / 20 °C

With tetrabutylammomium bromide; hydrogen; potassium carbonate; 10percent Pd/C; In ethanol; dichloromethane; dimethyl sulfoxide;

DOI:10.1002/1521-3765(20010504)7:9<1889::AID-CHEM1889>3.0.CO;2-7

upstream raw materials:

2-[6-[bis[(1,1-dimethylethoxy)carbonyl]amino]-1,4-dihydro-4-oxo-2-pyridinyl]-1,3-bis(1,1-dimethylethyl)ester

Benzyl bromoacetate

4?benzyloxy?2,6?diaminopyridine

di-tert-butyl(4-(benzyloxy)pyridine-2,6-diyl)bis(tert-butoxycarbonylcarbamate)

Downstream raw materials:

{1-[6-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-pyridin-2-ylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

4-Benzyloxy-2,6-bis(N-tert-butoxycarbonyl-L-phenylalaninylamino)pyridine

Benzyl 2-{[2,6-bis(N-tert-butoxycarbonyl-L-phenylalanylamino)-4-pyridyl]oxy} acetate

2-{2,6-Bis[N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-4-pyridyloxy} acetic acid