(2S)-2-aminobutanamide Hydrochloride

Base Information

• Chemical Name: (2S)-2-aminobutanamide Hydrochloride
• CAS No.: 7682-20-4
• Molecular Formula: C₄H₁₀N₂O*ClH
• Molecular Weight: 138.597
• Hs Code.: 29241990
• European Community (EC) Number: 471-490-5,616-393-2
• UNII: 2C1V4527RJ
• DSSTox Substance ID: DTXSID10474839
• Mol file: 7682-20-4.mol

Synonyms:7682-20-4;(S)-2-Aminobutyramide hydrochloride;(S)-2-Aminobutanamide hydrochloride;(2S)-2-aminobutanamide Hydrochloride;h-abu-nh2 hcl;L-2-Aminobutanamide hydrochloride;(S)-(+)-2-Aminobutanamide hydrochloride;(2S)-2-aminobutanamide;hydrochloride;l-homoalanylamide hcl;141978-61-2;Butanamide, 2-amino-, monohydrochloride, (2S)-;L-2-Aminobutanamide, HCl;2C1V4527RJ;(S)-2-Aminobutyramide (hydrochloride);Butanamide, 2-amino-, monohydrochloride, (S)-;Butanamide, 2-amino-, hydrochloride (1:1), (2S)-;h-abu(2)-nh2 hcl;(S)-2-Aminobutanamide HCl;(s)-2-amino butanamide hcl;(s)-2-amino-butanamide hcl;MFCD00136565;h-abu-nh2hcl;(S)-2-amino-butanamide hydrochloride;s (+)-2-aminobutyramide hydrochloride;1217605-54-3;l-2-aminobutanamide hcl;H-Abu(2)-NH2.HCl;SCHEMBL373444;UNII-2C1V4527RJ;L-Homoalanylamide hydrochloride;(s)-2-amino-butylactamide hcl;DTXSID10474839;S-2-Aminobutanamide hydrochloride;HDBMIDJFXOYCGK-DFWYDOINSA-N;CS-B0864;H-Abu-NH2 hydrochloride, AldrichCPR;AKOS015910759;DS-1209;Butanamide,2-amino-,hydrochloride(1:1);AC-23986;HY-79491;AM20100759;(S)-2-Aminobutanamide hydrochloride [USP-RS];(S)-(+)-2-Aminobutanamide hydrochloride, 97%;EN300-7375395;A935960;(2S)-2-Aminobutanamide--hydrogen chloride (1/1);BUTYRAMIDE, 2-AMINO-, MONOHYDROCHLORIDE, L-;Q-102786;Z1450533799

Chemical Property of (2S)-2-aminobutanamide Hydrochloride

Chemical Property:

• Appearance/Colour: Off-white solid
• Vapor Pressure: 0.00424mmHg at 25°C
• Melting Point: 259-263 °C
• Boiling Point: 245.7 °C at 760 mmHg
• Flash Point: 102.4 °C
• PSA: 69.11000
• LogP: 1.41160
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly), Water (Slightly)
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 138.0559907
• Heavy Atom Count: 8
• Complexity: 72.1

Purity/Quality:

99% ^*data from raw suppliers

(S)-2-Aminobutyramide Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36/37-36/37/38

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C(=O)N)N.Cl
• Isomeric SMILES: CC[C@@H](C(=O)N)N.Cl
• Uses: Levetiracetam USP Related Compound B

Technology Process of (2S)-2-aminobutanamide Hydrochloride

There total 14 articles about (2S)-2-aminobutanamide Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.6%

L-2-aminobutanamide tartaric acid (868134-59-2) → (S)-2-amino-butanamide hydrochloride (53726-14-0,7682-20-4,141978-61-2)

Guidance literature:

With hydrogenchloride; In water; acetone; at 20 ℃; for 5h; Solvent;

Reference yield: 96.18%

DL-2-aminobutanamide (53726-14-0) + L-Tartaric acid (87-69-4,138508-61-9) → (S)-2-amino-butanamide hydrochloride (53726-14-0,7682-20-4,141978-61-2)

Guidance literature:

DL-2-aminobutanamide; L-Tartaric acid; With Glyceraldehyde; In ethanol; at 70 ℃; for 6h; Resolution of racemate;

With hydrogenchloride; In ethanol; water; for 1.5h;

Reference yield: 96.0%

(S)-2-amino-butanamide (7324-11-0,53726-14-0,104652-77-9,143164-46-9) → (S)-2-amino-butanamide hydrochloride (53726-14-0,7682-20-4,141978-61-2)

Guidance literature:

With hydrogenchloride; In ethanol; at 20 - 30 ℃; for 2h; Reflux;

upstream raw materials:

2-aminobutyronitrile

(±)-2‐((benzylidene)amino)butanamide

α-aminobutyramide hydrobromide

tert-butyl N-[(1S)-1-carbamoylpropyl]carbamate

Downstream raw materials:

Boc-Tyr-Abu-NH₂

Refernces

• 1、 -. "Preparation method of L-2-aminobutanamide hydrochloride". Paragraph 0020; 0023; 0029; 0032; 0038; 0041. . Retrieved 2021/06/21.
• 2、 -. "Preparation method of (S)-(+)-2-aminobutanamide hydrochloride". Paragraph 0032; 0038-0043; 0049-0054; 0060-0065; 0071-0076. . Retrieved 2020/08/02.