6-[(3R,6S)-6-(2-isocyanato-2-methylpropyl)-1-(toluene-4-sulphonyl)piperidin-3-yloxymethyl]-4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazine

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Chemical Name:6-[(3R,6S)-6-(2-isocyanato-2-methylpropyl)-1-(toluene-4-sulphonyl)piperidin-3-yloxymethyl]-4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazine
CAS No.:959938-03-5
Molecular Formula:C₃₀H₄₁N₃O₆S
Molecular Weight:571.738
Hs Code.:

Synonyms:6-[(3R,6S)-6-(2-isocyanato-2-methylpropyl)-1-(toluene-4-sulphonyl)piperidin-3-yloxymethyl]-4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazine

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Chemical Property of 6-[(3R,6S)-6-(2-isocyanato-2-methylpropyl)-1-(toluene-4-sulphonyl)piperidin-3-yloxymethyl]-4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazine

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Technology Process of 6-[(3R,6S)-6-(2-isocyanato-2-methylpropyl)-1-(toluene-4-sulphonyl)piperidin-3-yloxymethyl]-4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazine

There total 21 articles about 6-[(3R,6S)-6-(2-isocyanato-2-methylpropyl)-1-(toluene-4-sulphonyl)piperidin-3-yloxymethyl]-4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₄₁N₅O₆S

: 959938-03-5
6-[(3R,6S)-6-(2-isocyanato-2-methylpropyl)-1-(toluene-4-sulphonyl)piperidin-3-yloxymethyl]-4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazine

Guidance literature:: In toluene; at 115 ℃; for 2h;

Reference yield:

: 959937-57-6
3-[(2S,5R)-5-(4-methoxybenzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]-2,2-dimethylpropionic acid methyl ester

: 959938-03-5
6-[(3R,6S)-6-(2-isocyanato-2-methylpropyl)-1-(toluene-4-sulphonyl)piperidin-3-yloxymethyl]-4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazine

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h

2.1: tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 3 h / 20 °C

3.1: methanol; sodium hydroxide; water / tetrahydrofuran / 4 h / 20 - 60 °C

3.2: 20 °C

4.1: triethylamine / tetrahydrofuran / 1 h / 0 °C

5.1: sodium azide / tetrahydrofuran; water / 0.75 h / 0 °C

6.1: toluene / 2 h / 115 °C

With methanol; sodium hydroxide; sodium azide; water; hydrogen; tetra-(n-butyl)ammonium iodide; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 857272-02-7
6-chloromethyl-4-(3-methoxy-propyl)-4H-benzo[1,4]oxazin-3-one

: 959938-03-5
6-[(3R,6S)-6-(2-isocyanato-2-methylpropyl)-1-(toluene-4-sulphonyl)piperidin-3-yloxymethyl]-4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazine

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 3 h / 20 °C

2.1: methanol; sodium hydroxide; water / tetrahydrofuran / 4 h / 20 - 60 °C

2.2: 20 °C

3.1: triethylamine / tetrahydrofuran / 1 h / 0 °C

4.1: sodium azide / tetrahydrofuran; water / 0.75 h / 0 °C

5.1: toluene / 2 h / 115 °C

With methanol; sodium hydroxide; sodium azide; water; tetra-(n-butyl)ammonium iodide; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;