7-[3-[4-(1-benzylindol-4-yl)piperazin-1-yl]propoxy]-3,4-dihydro-1H-quinolin-2-one

Base Information

Chemical Name:7-[3-[4-(1-benzylindol-4-yl)piperazin-1-yl]propoxy]-3,4-dihydro-1H-quinolin-2-one
CAS No.:1416970-46-1
Molecular Formula:C₃₁H₃₄N₄O₂
Molecular Weight:494.637
Hs Code.:

Synonyms:7-[3-[4-(1-benzylindol-4-yl)piperazin-1-yl]propoxy]-3,4-dihydro-1H-quinolin-2-one

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Chemical Property of 7-[3-[4-(1-benzylindol-4-yl)piperazin-1-yl]propoxy]-3,4-dihydro-1H-quinolin-2-one

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Technology Process of 7-[3-[4-(1-benzylindol-4-yl)piperazin-1-yl]propoxy]-3,4-dihydro-1H-quinolin-2-one

There total 4 articles about 7-[3-[4-(1-benzylindol-4-yl)piperazin-1-yl]propoxy]-3,4-dihydro-1H-quinolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82657-32-7
7-(3-bromopropoxy)-3,4-dihydroquinolin-2(1H)-one

: 1-benzyl-4-(piperazin-1-yl)-1H-indole hydrochloride

: 1416970-46-1
7-[3-[4-(1-benzylindol-4-yl)piperazin-1-yl]propoxy]-3,4-dihydro-1H-quinolin-2-one

Guidance literature:: With triethylamine; potassium iodide; In acetonitrile; at 70 ℃; for 8h;

Reference yield:

: 252978-89-5
4-(1H-indol-4-yl)-piperazine-1-carboxylic acid tert-butyl ester

: 1416970-46-1
7-[3-[4-(1-benzylindol-4-yl)piperazin-1-yl]propoxy]-3,4-dihydro-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / 0.33 h / 0 °C

1.2: 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 0.33 h / 20 °C

3.1: triethylamine; potassium iodide / acetonitrile / 8 h / 70 °C

With hydrogenchloride; 18-crown-6 ether; potassium tert-butylate; triethylamine; potassium iodide; In tetrahydrofuran; 1,4-dioxane; acetonitrile;

Reference yield:

: 100-39-0
benzyl bromide

: 1416970-46-1
7-[3-[4-(1-benzylindol-4-yl)piperazin-1-yl]propoxy]-3,4-dihydro-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / 0.33 h / 0 °C

1.2: 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 0.33 h / 20 °C

3.1: triethylamine; potassium iodide / acetonitrile / 8 h / 70 °C

With hydrogenchloride; 18-crown-6 ether; potassium tert-butylate; triethylamine; potassium iodide; In tetrahydrofuran; 1,4-dioxane; acetonitrile;