(4R)-3-[(2R,4R)-6-(benzyloxymethyl)-4-(tert-butoxy)-3,4-dihydro-2H-pyran-2-yl]-4-ethyl-1,3-oxazolidin-2-one

Base Information

Chemical Name:(4R)-3-[(2R,4R)-6-(benzyloxymethyl)-4-(tert-butoxy)-3,4-dihydro-2H-pyran-2-yl]-4-ethyl-1,3-oxazolidin-2-one
CAS No.:725258-13-9
Molecular Formula:C₂₂H₃₁NO₅
Molecular Weight:389.492
Hs Code.:

Synonyms:(4R)-3-[(2R,4R)-6-(benzyloxymethyl)-4-(tert-butoxy)-3,4-dihydro-2H-pyran-2-yl]-4-ethyl-1,3-oxazolidin-2-one

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Chemical Property of (4R)-3-[(2R,4R)-6-(benzyloxymethyl)-4-(tert-butoxy)-3,4-dihydro-2H-pyran-2-yl]-4-ethyl-1,3-oxazolidin-2-one

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Technology Process of (4R)-3-[(2R,4R)-6-(benzyloxymethyl)-4-(tert-butoxy)-3,4-dihydro-2H-pyran-2-yl]-4-ethyl-1,3-oxazolidin-2-one

There total 4 articles about (4R)-3-[(2R,4R)-6-(benzyloxymethyl)-4-(tert-butoxy)-3,4-dihydro-2H-pyran-2-yl]-4-ethyl-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: 725258-07-1
(4R)-3-[(2R,4R)-4-(tert-butoxy)-6-(hydroxymethyl)-3,4-dihydro-2H-pyran-2-yl]-4-ethyl-1,3-oxazolidin-2-one

: 725258-13-9
(4R)-3-[(2R,4R)-6-(benzyloxymethyl)-4-(tert-butoxy)-3,4-dihydro-2H-pyran-2-yl]-4-ethyl-1,3-oxazolidin-2-one

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1021/jo040102y

Reference yield:

: 207557-90-2
4-tert-butoxymethylenepyruvic acid methyl ester

: 725258-13-9
(4R)-3-[(2R,4R)-6-(benzyloxymethyl)-4-(tert-butoxy)-3,4-dihydro-2H-pyran-2-yl]-4-ethyl-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: Eu(fod)3 / cyclohexane / 120 h / Heating

2: DIBAH; BF₃*Et₂O / toluene; CH₂Cl₂ / -78 °C

3: sodium hydride / dimethylformamide; various solvent(s) / 3 h / 20 °C

With boron trifluoride diethyl etherate; sodium hydride; diisobutylaluminium hydride; Eu(fod)3; In dichloromethane; cyclohexane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo040102y

Reference yield:

: 634916-95-3
(4R)-4-ethyl-3-vinyl-oxazolidin-2-one

: 725258-13-9
(4R)-3-[(2R,4R)-6-(benzyloxymethyl)-4-(tert-butoxy)-3,4-dihydro-2H-pyran-2-yl]-4-ethyl-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: Eu(fod)3 / cyclohexane / 120 h / Heating

2: DIBAH; BF₃*Et₂O / toluene; CH₂Cl₂ / -78 °C

3: sodium hydride / dimethylformamide; various solvent(s) / 3 h / 20 °C

With boron trifluoride diethyl etherate; sodium hydride; diisobutylaluminium hydride; Eu(fod)3; In dichloromethane; cyclohexane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo040102y