Methylglucamine

Base Information

• Chemical Name: Methylglucamine
• CAS No.: 6284-40-8
• Molecular Formula: C7H17NO5
• Molecular Weight: 195.216
• Hs Code.: 2922.19
• NSC Number: 52907,7391
• DSSTox Substance ID: DTXSID70859264
• Nikkaji Number: J25.796F
• Wikidata: Q27167037
• ChEMBL ID: CHEMBL333195
• Mol file: 6284-40-8.mol

Synonyms:Meglumine;Methylglucamine

Chemical Property of Methylglucamine

Chemical Property:

• Appearance/Colour: white to almost white crystalline powder
• Vapor Pressure: 1.12E-11mmHg at 25°C
• Melting Point: 129-131.5 °C(lit.)
• Refractive Index: -16.5 ° (C=2, H2O)
• Boiling Point: 490.4 °C at 760 mmHg
• PKA: pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate)
• Flash Point: 251.6 °C
• PSA: 113.18000
• Density: 1.375 g/cm³
• LogP: -2.96740
• Storage Temp.: Store below +30°C.
• Sensitive.: Air Sensitive & Hygroscopic
• Solubility.: H2O: 0.1 g/mL, clear, colorless
• Water Solubility.: 100 g/100 mL (25 ºC)
• XLogP3: -2.8
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 195.11067264
• Heavy Atom Count: 13
• Complexity: 134

Purity/Quality:

99% ^*data from raw suppliers

N-Methyl-D-glucamine ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNCC(C(C(C(CO)O)O)O)O
• Uses: antiinflammatory excipient in cosmetics and X-ray contrast media N-Methyl-D-glucamine is used in conjunction with iodinated organic compounds in contrast media viz. diatrizoate meglumine and iodipamide meglumine. It is useful in ion-exchange resins to chelate boron ions selectively. It is also used as an excipient in pharmaceuticals, in cosmetics and X-ray contrast media. It is also employed in the synthesis of surface active agents, pharmaceuticals and dyes.

Technology Process of Methylglucamine

There total 9 articles about Methylglucamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.3%

N-methyl-D-gluconamide (24758-59-6) → 1-deoxy-1-(methylamino)-D-glucitol (6284-40-8,97780-33-1)

Guidance literature:

With ammonia borane; palladium/alumina; at 78 ℃; for 2h; under 975.098 - 48004.8 Torr; Temperature; Pressure; Reagent/catalyst; Inert atmosphere; Large scale;

Reference yield: 62.5%

D-glucose (50-99-7) + methylamine (74-89-5) → 1-deoxy-1-(methylamino)-D-glucitol (6284-40-8,97780-33-1)

Guidance literature:

With hydrogen; In water; at 10 - 100 ℃; for 21.5h; under 5171.62 - 25858.1 Torr;

Reference yield:

D-glucose (50-99-7) → 1-deoxy-1-(methylamino)-D-glucitol (6284-40-8,97780-33-1)

Guidance literature:

With methylamine;

upstream raw materials:

D-glucose

methylamine

methylaminomethanol

magnesium stearate

Downstream raw materials:

methyl-D-fructos-1-yl-dithiocarbamic acid

Bis-O--hexoestrol

1--phenylcarbamoyl)-amino>-1-desoxy-D-glucit

1--phenyl-thiocarbamoyl)-amino>-1-desoxy-D-glucit

Refernces

• 1、 Pelckmans, Michiel,Vermandel, Walter,Van Waes, Frederik,Moonen, Kristof,Sels, Bert F.. "Low-Temperature Reductive Aminolysis of Carbohydrates to Diamines and Aminoalcohols by Heterogeneous Catalysis". . p. 14540 - 14544. Retrieved 2017/10/23.
• 2、 Rajabi, Fatemeh,Luque, Rafael. "An efficient renewable-derived surfactant for aqueous esterification reactions". . p. 5152 - 5155. Retrieved 2014/01/23.