1-methyl-2-N-(1-(+/-)-phenylethylamino)prop-1-enyldiphenylphosphine oxide

Base Information

• Chemical Name: 1-methyl-2-N-(1-(+/-)-phenylethylamino)prop-1-enyldiphenylphosphine oxide
• CAS No.: 349547-99-5
• Molecular Formula: C₂₄H₂₆NOP
• Molecular Weight: 375.45
• Mol file: 349547-99-5.mol

Synonyms:1-methyl-2-N-(1-(+/-)-phenylethylamino)prop-1-enyldiphenylphosphine oxide

Chemical Property of 1-methyl-2-N-(1-(+/-)-phenylethylamino)prop-1-enyldiphenylphosphine oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methyl-2-N-(1-(+/-)-phenylethylamino)prop-1-enyldiphenylphosphine oxide

There total 1 articles about 1-methyl-2-N-(1-(+/-)-phenylethylamino)prop-1-enyldiphenylphosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

[(Z)-2-(Diphenyl-phosphinoyl)-1-methyl-vinyl]-(1-phenyl-ethyl)-amine + methyl iodide (74-88-4) → 1-methyl-2-N-(1-(+/-)-phenylethylamino)prop-1-enyldiphenylphosphine oxide (349547-99-5)

Guidance literature:

[(Z)-2-(Diphenyl-phosphinoyl)-1-methyl-vinyl]-(1-phenyl-ethyl)-amine; With methyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

methyl iodide; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1016/S0040-4020(01)00171-5

Reference yield: 70.0%

glyoxylic acid ethyl ester (924-44-7) + 1-methyl-2-N-(1-(+/-)-phenylethylamino)prop-1-enyldiphenylphosphine oxide (349547-99-5) → ethyl 3-methyl-4-[1-(+/-)-phenylethyl]imino-2-pentenoate (349548-10-3)

Guidance literature:

1-methyl-2-N-(1-(+/-)-phenylethylamino)prop-1-enyldiphenylphosphine oxide; With methyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

glyoxylic acid ethyl ester; In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1016/S0040-4020(01)00171-5

Reference yield:

1-methyl-2-N-(1-(+/-)-phenylethylamino)prop-1-enyldiphenylphosphine oxide (349547-99-5) → ethyl 3-methyl-4-[1-phenylethyl]amino-2-pentenoate

Guidance literature:

Multi-step reaction with 2 steps

1.1: methyllithium / tetrahydrofuran / 1 h / -78 °C

1.2: 70 percent / tetrahydrofuran / 12 h / 20 °C

2.1: 98 mg / NaBH(OAc)3 / tetrahydrofuran; acetonitrile / 0 °C

With methyllithium; sodium tris(acetoxy)borohydride; In tetrahydrofuran; acetonitrile; 1.2: Wittig-Horner olefination;

DOI:10.1016/S0040-4020(01)00171-5

upstream raw materials:

methyl iodide

Downstream raw materials:

ethyl 3-methyl-4-[1-(+/-)-phenylethyl]imino-2-pentenoate

Refernces