2a-[4-{4-(2-Cyanophenyl)piperazinyl}butyl]-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one

Base Information

Chemical Name:2a-[4-{4-(2-Cyanophenyl)piperazinyl}butyl]-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one
CAS No.:201608-78-8
Molecular Formula:C₂₆H₃₀N₄O
Molecular Weight:414.55
Hs Code.:

Synonyms:2a-[4-{4-(2-Cyanophenyl)piperazinyl}butyl]-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one

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Chemical Property of 2a-[4-{4-(2-Cyanophenyl)piperazinyl}butyl]-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one

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Technology Process of 2a-[4-{4-(2-Cyanophenyl)piperazinyl}butyl]-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one

There total 5 articles about 2a-[4-{4-(2-Cyanophenyl)piperazinyl}butyl]-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 111373-03-6
2-(piperazin-1-yl)benzonitrile

: 201609-25-8
2a-(4-bromobutyl)-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one

: 201608-78-8
2a-[4-{4-(2-Cyanophenyl)piperazinyl}butyl]-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 96h;
DOI:10.1021/jm0104264

Reference yield: 97.0%

: 201609-31-6
2a-(3-Formylpropyl)-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one

: 111373-03-6
2-(piperazin-1-yl)benzonitrile

: 201608-78-8
2a-[4-{4-(2-Cyanophenyl)piperazinyl}butyl]-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one

Guidance literature:

Reference yield:

: 96933-21-0
(RS)-2a,3,4,5-tetrahydro-1H-benz[cd]indol-2-one

: 201608-78-8
2a-[4-{4-(2-Cyanophenyl)piperazinyl}butyl]-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 1 h / 0 °C

1.2: 54 percent / dimethylformamide / 0.5 h / 0 °C

2.1: 97 percent / K₂CO₃ / dimethylformamide / 96 h / 20 °C

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm0104264