MOA-Phe-Phe-Lys(pEBA)-OH

Base Information

• Chemical Name: MOA-Phe-Phe-Lys(pEBA)-OH
• CAS No.: 1187396-30-0
• Molecular Formula: C₄₅H₆₁N₅O₆
• Molecular Weight: 768.009
• Mol file: 1187396-30-0.mol

Synonyms:MOA-Phe-Phe-Lys(pEBA)-OH

Chemical Property of MOA-Phe-Phe-Lys(pEBA)-OH

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of MOA-Phe-Phe-Lys(pEBA)-OH

There total 2 articles about MOA-Phe-Phe-Lys(pEBA)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

p-ethylbenzoic acid (619-64-7) + (+)-menthyloxyacetic acid (94133-41-2) + N-Fmoc L-Phe (35661-40-6) + (S)-6-allyloxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoic acid (146982-27-6) → MOA-Phe-Phe-Lys(pEBA)-OH (1187396-30-0)

Guidance literature:

(S)-6-allyloxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoic acid; With 4-methyl-morpholine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; for 2h;

With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; acetic acid; In dichloromethane; Rink amide resin Inert atmosphere;

p-ethylbenzoic acid; (+)-menthyloxyacetic acid; N-Fmoc L-Phe; Further stages;

Reference yield:

C45H60N5O6Pol → MOA-Phe-Phe-Lys(pEBA)-OH (1187396-30-0)

Guidance literature:

With chlorotriisopropylsilane; water; trifluoroacetic acid; In dichloromethane; solid phase reaction;

DOI:10.1021/ja903733z

upstream raw materials:

p-ethylbenzoic acid

(+)-menthyloxyacetic acid

N-Fmoc L-Phe

(S)-6-allyloxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoic acid

Refernces

• 1、 -. "Inhibitors of protein tyrosine phosphatases". Paragraph 0059; 0060; 0082; 0083. . Retrieved 2016/01/09.