phenyl 3-acetoxy-5-(2-ethoxy-1,1-difluoro-2-oxoethyl)-3,4-dihydro-2H-pyridine-1-carboxylate

Base Information

Chemical Name:phenyl 3-acetoxy-5-(2-ethoxy-1,1-difluoro-2-oxoethyl)-3,4-dihydro-2H-pyridine-1-carboxylate
CAS No.:1609582-78-6
Molecular Formula:C₁₈H₁₉F₂NO₆
Molecular Weight:383.349
Hs Code.:

Synonyms:phenyl 3-acetoxy-5-(2-ethoxy-1,1-difluoro-2-oxoethyl)-3,4-dihydro-2H-pyridine-1-carboxylate

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Chemical Property of phenyl 3-acetoxy-5-(2-ethoxy-1,1-difluoro-2-oxoethyl)-3,4-dihydro-2H-pyridine-1-carboxylate

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Technology Process of phenyl 3-acetoxy-5-(2-ethoxy-1,1-difluoro-2-oxoethyl)-3,4-dihydro-2H-pyridine-1-carboxylate

There total 4 articles about phenyl 3-acetoxy-5-(2-ethoxy-1,1-difluoro-2-oxoethyl)-3,4-dihydro-2H-pyridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 667-27-6
Ethyl bromodifluoroacetate

: 1609582-93-5
1-(phenyloxycarbonyl)-3-acetoxy-1,2,3,4-tetrahydropyridine

: 1609582-78-6
phenyl 3-acetoxy-5-(2-ethoxy-1,1-difluoro-2-oxoethyl)-3,4-dihydro-2H-pyridine-1-carboxylate

Guidance literature:: With copper(I) oxide; 1,10-Phenanthroline; potassium carbonate; In acetonitrile; at 80 ℃; for 23h; regioselective reaction; Inert atmosphere; Sealed tube;
DOI:10.1039/c4cc01994f

Reference yield:

: 109-00-2
3-HYDROXYPYRIDINE

: 1609582-78-6
phenyl 3-acetoxy-5-(2-ethoxy-1,1-difluoro-2-oxoethyl)-3,4-dihydro-2H-pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate; sodium hydrogencarbonate / ethanol / 6 h / -78 °C

2: triethylamine; dmap / dichloromethane / 2.5 h / 20 °C

3: potassium carbonate; copper(I) oxide; 1,10-Phenanthroline / acetonitrile / 23 h / 80 °C / Inert atmosphere; Sealed tube

With copper(I) oxide; dmap; sodium tetrahydroborate; 1,10-Phenanthroline; sodium hydrogencarbonate; potassium carbonate; triethylamine; In ethanol; dichloromethane; acetonitrile;
DOI:10.1039/c4cc01994f

Reference yield:

: 1885-14-9
phenyl chloroformate

: 1609582-78-6
phenyl 3-acetoxy-5-(2-ethoxy-1,1-difluoro-2-oxoethyl)-3,4-dihydro-2H-pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate; sodium hydrogencarbonate / ethanol / 6 h / -78 °C

2: triethylamine; dmap / dichloromethane / 2.5 h / 20 °C

3: potassium carbonate; copper(I) oxide; 1,10-Phenanthroline / acetonitrile / 23 h / 80 °C / Inert atmosphere; Sealed tube

With copper(I) oxide; dmap; sodium tetrahydroborate; 1,10-Phenanthroline; sodium hydrogencarbonate; potassium carbonate; triethylamine; In ethanol; dichloromethane; acetonitrile;
DOI:10.1039/c4cc01994f