ethyl 2-{1-[(4-methylphenyl)sulfonyl]-6-oxo-1,2,3,6-tetrahydro-4-pyridinyl}acetate

Base Information

Chemical Name:ethyl 2-{1-[(4-methylphenyl)sulfonyl]-6-oxo-1,2,3,6-tetrahydro-4-pyridinyl}acetate
CAS No.:411240-91-0
Molecular Formula:C₁₆H₁₉NO₅S
Molecular Weight:337.397
Hs Code.:

Synonyms:ethyl 2-{1-[(4-methylphenyl)sulfonyl]-6-oxo-1,2,3,6-tetrahydro-4-pyridinyl}acetate

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Chemical Property of ethyl 2-{1-[(4-methylphenyl)sulfonyl]-6-oxo-1,2,3,6-tetrahydro-4-pyridinyl}acetate

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Technology Process of ethyl 2-{1-[(4-methylphenyl)sulfonyl]-6-oxo-1,2,3,6-tetrahydro-4-pyridinyl}acetate

There total 3 articles about ethyl 2-{1-[(4-methylphenyl)sulfonyl]-6-oxo-1,2,3,6-tetrahydro-4-pyridinyl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 141-97-9
ethyl acetoacetate

: 317339-72-3
4-(phenylsulfonyl)-1-tosyl-5,6-dihydro-2-pyridone

: 411240-91-0
ethyl 2-{1-[(4-methylphenyl)sulfonyl]-6-oxo-1,2,3,6-tetrahydro-4-pyridinyl}acetate

Guidance literature:: ethyl acetoacetate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

4-(phenylsulfonyl)-1-tosyl-5,6-dihydro-2-pyridone; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1055/s-2001-18710

Reference yield:

: 4083-64-1
Tosyl isocyanate

: 411240-91-0
ethyl 2-{1-[(4-methylphenyl)sulfonyl]-6-oxo-1,2,3,6-tetrahydro-4-pyridinyl}acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 71 percent / hydroquinone; NaHCO₃ / toluene / 4.5 h / 110 °C

2.1: 98 percent / m-CPBA / CH₂Cl₂ / 1.5 h / 20 °C

3.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

3.2: 35 percent / tetrahydrofuran / 2 h / 20 °C

With sodium hydride; sodium hydrogencarbonate; hydroquinone; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; toluene; 1.1: aza-Diels-Alder reaction;
DOI:10.1055/s-2001-18710

Reference yield:

: 317339-60-9
4-phenylsulfanyl-1-(toluene-4-sulfonyl)-5,6-dihydro-1H-pyridin-2-one

: 411240-91-0
ethyl 2-{1-[(4-methylphenyl)sulfonyl]-6-oxo-1,2,3,6-tetrahydro-4-pyridinyl}acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 98 percent / m-CPBA / CH₂Cl₂ / 1.5 h / 20 °C

2.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

2.2: 35 percent / tetrahydrofuran / 2 h / 20 °C

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-2001-18710