2-nitro-6-{[4-(trifluoromethoxy)phenoxy]methyl}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Base Information

Chemical Name:2-nitro-6-{[4-(trifluoromethoxy)phenoxy]methyl}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
CAS No.:1263187-73-0
Molecular Formula:C₁₄H₁₂F₃N₃O₅
Molecular Weight:359.262
Hs Code.:

Synonyms:2-nitro-6-{[4-(trifluoromethoxy)phenoxy]methyl}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

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Chemical Property of 2-nitro-6-{[4-(trifluoromethoxy)phenoxy]methyl}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

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Technology Process of 2-nitro-6-{[4-(trifluoromethoxy)phenoxy]methyl}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

There total 6 articles about 2-nitro-6-{[4-(trifluoromethoxy)phenoxy]methyl}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1263188-75-5
3-(2-bromo-4-nitro-1H-imidazol-1-yl)-2-{[4-(trifluoromethoxy)phenoxy]methyl}propan-1-ol

: 1263187-73-0
2-nitro-6-{[4-(trifluoromethoxy)phenoxy]methyl}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 5h; Sealed tube; Inert atmosphere;
DOI:10.1021/acs.jmedchem.7b01581

Reference yield: 69.0%

: 1263187-73-0
2-nitro-6-{[4-(trifluoromethoxy)phenoxy]methyl}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Guidance literature:

Reference yield:

: 1263188-71-1
tert-butyldimethyl[(2-{[4-(trifluoromethoxy)phenoxy]methyl}allyl)oxy]silane

: 1263187-73-0
2-nitro-6-{[4-(trifluoromethoxy)phenoxy]methyl}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Guidance literature:: Multi-step reaction with 5 steps

1.1: iodine; sodium tetrahydroborate / tetrahydrofuran / 17 h / 0 - 20 °C

1.2: 3 h / 0 - 20 °C

2.1: iodine; triphenylphosphine; 1H-imidazole / dichloromethane / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 82 - 87 °C

4.1: hydrogenchloride / ethanol; water / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; iodine; sodium hydride; potassium carbonate; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2015.07.084