Technology Process of (3aS,4S,6aR)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-2,2-dimethyl-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-ol
There total 21 articles about (3aS,4S,6aR)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-2,2-dimethyl-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate; cerium(III) chloride;
In
methanol;
at 0 - 5 ℃;
for 0.5h;
DOI:10.1016/j.tet.2007.06.100
- Guidance literature:
-
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
dichloromethane;
at 20 ℃;
for 24h;
Inert atmosphere;
DOI:10.1021/jo302038d
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 100 percent / triethylamine; DMAP / CH2Cl2 / 3 h / 20 °C
2.1: potassium tert-butoxide / tetrahydrofuran / 0 - 20 °C
2.2: 86 percent / tetrahydrofuran / 7 h / 0 - 20 °C
3.1: 99 percent / oxalyl chloride; DMSO; triethylamine / CH2Cl2 / -78 - 20 °C
4.1: 96 percent / tetrahydrofuran / 1 h / -78 °C
5.1: 95 percent / Neolyst dichlorideTM / CH2Cl2 / 48 h / 20 °C
6.1: 90 percent / pyridinium dichromate; 4 Angstroem molecular sieves / dimethylformamide / 48 h / 20 °C
7.1: 99 percent / sodium borohydride; cerium(III) chloride heptahydrate / methanol / 0.5 h / 0 - 5 °C
With
dmap; sodium tetrahydroborate; dipyridinium dichromate; cerium(III) chloride; oxalyl dichloride; 4 A molecular sieve; potassium tert-butylate; dimethyl sulfoxide; triethylamine;
Neolyst dichlorideTM;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
2.2: Wittig reaction / 3.1: Swern oxidation / 4.1: Grignard reaction / 7.1: Luche reduction;
DOI:10.1016/j.tet.2007.06.100
