2-(6-Ethyl-1-hydroxy-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-3-methoxy-benzoic acid

Base Information

Chemical Name:2-(6-Ethyl-1-hydroxy-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-3-methoxy-benzoic acid
CAS No.:78772-96-0
Molecular Formula:C₂₁H₂₂O₅
Molecular Weight:354.403
Hs Code.:

Synonyms:2-(6-Ethyl-1-hydroxy-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-3-methoxy-benzoic acid

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Chemical Property of 2-(6-Ethyl-1-hydroxy-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-3-methoxy-benzoic acid

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Technology Process of 2-(6-Ethyl-1-hydroxy-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-3-methoxy-benzoic acid

There total 6 articles about 2-(6-Ethyl-1-hydroxy-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-3-methoxy-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 78772-95-9
2-(6-Ethyl-1-hydroxy-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-3-methoxy-benzoic acid methyl ester

: 78772-96-0
2-(6-Ethyl-1-hydroxy-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-3-methoxy-benzoic acid

Guidance literature:: With sodium hydroxide; In methanol; for 0.75h; Heating;
DOI:10.1021/ja00404a048

Reference yield:

: 33892-75-0
5-Methoxy-1-tetralone

: 78772-96-0
2-(6-Ethyl-1-hydroxy-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-3-methoxy-benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) potassium tert-butoxide, 2.) hydrogen, HCl / 2.) Pd/C / 1.) tert-butyl alcohol, 2.) HOAc

2: 48percent HBr / 120 °C

3: 90 percent / trifluoroacetic acid / CH₂Cl₂ / 5 h / Heating

4: 70 percent / boron trifluoride etherate / 0.17 h / 126 °C

5: 100 percent / NaOH / methanol / 0.75 h / Heating

With hydrogenchloride; sodium hydroxide; boron trifluoride diethyl etherate; potassium tert-butylate; hydrogen bromide; hydrogen; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/ja00404a048

Reference yield:

: 60314-07-0
2-methoxy-6-methoxycarbonylbenzoic acid

: 78772-96-0
2-(6-Ethyl-1-hydroxy-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-3-methoxy-benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / trifluoroacetic acid / CH₂Cl₂ / 5 h / Heating

2: 70 percent / boron trifluoride etherate / 0.17 h / 126 °C

3: 100 percent / NaOH / methanol / 0.75 h / Heating

With sodium hydroxide; boron trifluoride diethyl etherate; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1021/ja00404a048