2-(6-Ethyl-1-hydroxy-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-3-methoxy-benzoic acid methyl ester

Base Information

Chemical Name:2-(6-Ethyl-1-hydroxy-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-3-methoxy-benzoic acid methyl ester
CAS No.:78772-95-9
Molecular Formula:C₂₂H₂₄O₅
Molecular Weight:368.43
Hs Code.:

Synonyms:2-(6-Ethyl-1-hydroxy-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-3-methoxy-benzoic acid methyl ester

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Chemical Property of 2-(6-Ethyl-1-hydroxy-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-3-methoxy-benzoic acid methyl ester

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Technology Process of 2-(6-Ethyl-1-hydroxy-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-3-methoxy-benzoic acid methyl ester

There total 5 articles about 2-(6-Ethyl-1-hydroxy-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-3-methoxy-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 78772-93-7
3-Methoxy-phthalic acid 2-(6-ethyl-5,6,7,8-tetrahydro-naphthalen-1-yl) ester 1-methyl ester

: 78772-95-9
2-(6-Ethyl-1-hydroxy-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-3-methoxy-benzoic acid methyl ester

Guidance literature:: With boron trifluoride diethyl etherate; at 126 ℃; for 0.166667h;
DOI:10.1021/ja00404a048

Reference yield:

: 33892-75-0
5-Methoxy-1-tetralone

: 78772-95-9
2-(6-Ethyl-1-hydroxy-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-3-methoxy-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) potassium tert-butoxide, 2.) hydrogen, HCl / 2.) Pd/C / 1.) tert-butyl alcohol, 2.) HOAc

2: 48percent HBr / 120 °C

3: 90 percent / trifluoroacetic acid / CH₂Cl₂ / 5 h / Heating

4: 70 percent / boron trifluoride etherate / 0.17 h / 126 °C

With hydrogenchloride; boron trifluoride diethyl etherate; potassium tert-butylate; hydrogen bromide; hydrogen; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane;
DOI:10.1021/ja00404a048

Reference yield:

: 60314-07-0
2-methoxy-6-methoxycarbonylbenzoic acid

: 78772-95-9
2-(6-Ethyl-1-hydroxy-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-3-methoxy-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / trifluoroacetic acid / CH₂Cl₂ / 5 h / Heating

2: 70 percent / boron trifluoride etherate / 0.17 h / 126 °C

With boron trifluoride diethyl etherate; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ja00404a048