2-tert-butyl-5-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole trifluoroacetate

Base Information

Chemical Name:2-tert-butyl-5-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole trifluoroacetate
CAS No.:960391-14-4
Molecular Formula:C₂HF₃O₂*C₂₇H₃₆F₂N₄O₂
Molecular Weight:600.629
Hs Code.:

Synonyms:2-tert-butyl-5-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole trifluoroacetate

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Chemical Property of 2-tert-butyl-5-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole trifluoroacetate

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Technology Process of 2-tert-butyl-5-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole trifluoroacetate

There total 9 articles about 2-tert-butyl-5-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₃₂F₂N₄O

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 960391-14-4
2-tert-butyl-5-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole trifluoroacetate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 809273-66-3
methyl {[(4,4-difluorocyclohexyl)methanol]amino}-3-nitrobenzoate

: 960391-14-4
2-tert-butyl-5-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 48 h / 20 °C / 2585.81 Torr

2.1: dmap / dichloromethane / 4 h / 20 °C

3.1: acetic acid / 3 h / 150 °C / Microwave irradiation

4.1: lithium hydroxide; water / 1,4-dioxane / 3 h / 75 °C

4.2: pH 5 - 6

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

6.1: hydrogenchloride; acetic acid / 1 h / 20 °C

7.1: triethylamine / dichloromethane / 1 h / 20 °C

With hydrogenchloride; dmap; lithium hydroxide; water; hydrogen; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 809273-65-2
(4,4-difluorocyclohexane)methylamine hydrochloride

: 960391-14-4
2-tert-butyl-5-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 75 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 48 h / 20 °C / 2585.81 Torr

3.1: dmap / dichloromethane / 4 h / 20 °C

4.1: acetic acid / 3 h / 150 °C / Microwave irradiation

5.1: lithium hydroxide; water / 1,4-dioxane / 3 h / 75 °C

5.2: pH 5 - 6

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

7.1: hydrogenchloride; acetic acid / 1 h / 20 °C

8.1: triethylamine / dichloromethane / 1 h / 20 °C

With hydrogenchloride; dmap; lithium hydroxide; water; hydrogen; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;