tert-butyl (4-(7-(2-hydroxyethoxy)quinoxalin-2-yl)phenyl)(methyl)carbamate

Base Information

Chemical Name:tert-butyl (4-(7-(2-hydroxyethoxy)quinoxalin-2-yl)phenyl)(methyl)carbamate
CAS No.:1437281-31-6
Molecular Formula:C₂₂H₂₅N₃O₄
Molecular Weight:395.458
Hs Code.:

Synonyms:tert-butyl (4-(7-(2-hydroxyethoxy)quinoxalin-2-yl)phenyl)(methyl)carbamate

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Chemical Property of tert-butyl (4-(7-(2-hydroxyethoxy)quinoxalin-2-yl)phenyl)(methyl)carbamate

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Technology Process of tert-butyl (4-(7-(2-hydroxyethoxy)quinoxalin-2-yl)phenyl)(methyl)carbamate

There total 16 articles about tert-butyl (4-(7-(2-hydroxyethoxy)quinoxalin-2-yl)phenyl)(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1437281-29-2
tert-butyl (4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)phenyl)(methyl)carbamate

: 1437281-31-6
tert-butyl (4-(7-(2-hydroxyethoxy)quinoxalin-2-yl)phenyl)(methyl)carbamate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;
DOI:10.1021/ml4000707

Reference yield:

: 215656-99-8
4-{[tert-butyl(dimethyl)silyl]oxy}-2-nitroaniline

: 1437281-31-6
tert-butyl (4-(7-(2-hydroxyethoxy)quinoxalin-2-yl)phenyl)(methyl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: palladium on activated charcoal; hydrogen / methanol; dichloromethane / 7 h / 20 °C

2.1: dimethyl sulfoxide / 4 h / 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 - 50 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 105 °C

4.2: 105 °C

5.1: pyridine / 0 - 20 °C

6.1: tetrahydrofuran / 2 h / Reflux

6.2: 5 h / Reflux

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C

With pyridine; palladium on activated charcoal; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ml4000707

Reference yield:

: 1416374-31-6
4-((tert-butyldimethylsilyl)oxy)benzene-1,2-diamine

: 1437281-31-6
tert-butyl (4-(7-(2-hydroxyethoxy)quinoxalin-2-yl)phenyl)(methyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: dimethyl sulfoxide / 4 h / 20 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 - 50 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 105 °C

3.2: 105 °C

4.1: pyridine / 0 - 20 °C

5.1: tetrahydrofuran / 2 h / Reflux

5.2: 5 h / Reflux

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C

With pyridine; tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ml4000707