tert-butyl (4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)phenyl)(methyl)carbamate

Base Information

• Chemical Name: tert-butyl (4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)phenyl)(methyl)carbamate
• CAS No.: 1437281-29-2
• Molecular Formula: C₂₈H₃₉N₃O₄Si
• Molecular Weight: 509.721
• Mol file: 1437281-29-2.mol

Synonyms:tert-butyl (4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)phenyl)(methyl)carbamate

Chemical Property of tert-butyl (4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)phenyl)(methyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)phenyl)(methyl)carbamate

There total 16 articles about tert-butyl (4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)phenyl)(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.2%

di-tert-butyl dicarbonate (24424-99-5) + 4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)-N-methylaniline (1437281-26-9) → tert-butyl (4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)phenyl)(methyl)carbamate (1437281-29-2)

Guidance literature:

di-tert-butyl dicarbonate; 4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)-N-methylaniline; In tetrahydrofuran; at 80 ℃; for 2h;

With dmap; triethylamine; at 80 ℃; for 5h;

Reference yield: 81.2%

di-tert-butyl dicarbonate (24424-99-5) + 2-((3-(4-(dimethylamino)phenyl)quinoxalin-6-yl)oxy)ethyl 4-methylbenzenesulfonate (1437281-27-0) → tert-butyl (4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)phenyl)(methyl)carbamate (1437281-29-2)

Guidance literature:

di-tert-butyl dicarbonate; 2-((3-(4-(dimethylamino)phenyl)quinoxalin-6-yl)oxy)ethyl 4-methylbenzenesulfonate; In tetrahydrofuran; for 2h; Reflux;

With dmap; triethylamine; In tetrahydrofuran; for 5h; Reflux;

DOI:10.1021/ml4000707

Reference yield:

4-{[tert-butyl(dimethyl)silyl]oxy}-2-nitroaniline (215656-99-8) → tert-butyl (4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)phenyl)(methyl)carbamate (1437281-29-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: palladium on activated charcoal; hydrogen / methanol; dichloromethane / 7 h / 20 °C

2.1: dimethyl sulfoxide / 4 h / 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 - 50 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 105 °C

4.2: 105 °C

5.1: pyridine / 0 - 20 °C

6.1: tetrahydrofuran / 2 h / Reflux

6.2: 5 h / Reflux

With pyridine; palladium on activated charcoal; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/ml4000707

upstream raw materials:

2-((3-(4-(dimethylamino)phenyl)quinoxalin-6-yl)oxy)ethanol

di-tert-butyl dicarbonate

2-((3-(4-(dimethylamino)phenyl)quinoxalin-6-yl)oxy)ethyl 4-methylbenzenesulfonate

2,2-dibromo-1-(4-(dimethylamino)phenyl)ethan-1-one

Downstream raw materials:

tert-butyl (4-(7-(2-hydroxyethoxy)quinoxalin-2-yl)phenyl)(methyl)carbamate

2-((3-(4-((tert-butoxycarbonyl)(methyl)amino)phenyl)quinoxalin-6-yl)oxy)ethyl 4-methylbenzenesulfonate

4-(7-(2-[¹⁸F]fluoroethoxy)quinoxalin-2-yl)-N-methylaniline