Technology Process of 2-((3-(4-(dimethylamino)phenyl)quinoxalin-6-yl)oxy)ethanol
There total 8 articles about 2-((3-(4-(dimethylamino)phenyl)quinoxalin-6-yl)oxy)ethanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-(4-(dimethylamino)phenyl)quinoxalin-6-ol;
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 105 ℃;
for 0.5h;
2-bromoethanol;
In
N,N-dimethyl-formamide;
at 105 ℃;
DOI:10.1021/ml4000707
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: phosphonic acid diethyl ester; triethylamine / tetrahydrofuran / 11 h / 0 - 20 °C
2.1: dimethyl sulfoxide / 4 h / 20 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 - 50 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 105 °C
4.2: 105 °C
With
tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; phosphonic acid diethyl ester;
In
tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ml4000707
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: dimethyl sulfoxide / 4 h / 20 °C
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 - 50 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 105 °C
3.2: 105 °C
With
tetrabutyl ammonium fluoride; potassium carbonate;
In
tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ml4000707
