(S)-N-((3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-2-oxo-oxazolidin-5-yl)methyl)-2-hydroxyacetamide

Base Information

Chemical Name:(S)-N-((3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-2-oxo-oxazolidin-5-yl)methyl)-2-hydroxyacetamide
CAS No.:1293990-11-0
Molecular Formula:C₁₉H₁₈FN₇O₄
Molecular Weight:427.395
Hs Code.:

Synonyms:(S)-N-((3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-2-oxo-oxazolidin-5-yl)methyl)-2-hydroxyacetamide

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Chemical Property of (S)-N-((3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-2-oxo-oxazolidin-5-yl)methyl)-2-hydroxyacetamide

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Technology Process of (S)-N-((3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-2-oxo-oxazolidin-5-yl)methyl)-2-hydroxyacetamide

There total 9 articles about (S)-N-((3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-2-oxo-oxazolidin-5-yl)methyl)-2-hydroxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1293990-10-9
(S)-2-(benzyloxy)-N-((3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

: 1293990-11-0
(S)-N-((3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-2-oxo-oxazolidin-5-yl)methyl)-2-hydroxyacetamide

Guidance literature:: With 10% palladium on activated charcoal; hydrogen; at 20 ℃; for 48h;
DOI:10.1016/j.ejmech.2011.01.014

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 1293990-11-0
(S)-N-((3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-2-oxo-oxazolidin-5-yl)methyl)-2-hydroxyacetamide

Guidance literature:: Multi-step reaction with 9 steps

1: sodium cyanide / N,N-dimethyl-formamide / 7 h / 150 °C / Inert atmosphere

2: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 3 h / 110 °C / Inert atmosphere

3: sodium hydroxide / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

4: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / 1-methyl-pyrrolidin-2-one / 4 h / 120 °C / Inert atmosphere

5: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

6: sodium azide / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

7: 10% palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C

8: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

9: 10% palladium on activated charcoal; hydrogen / 48 h / 20 °C

With sodium cyanide; bis-triphenylphosphine-palladium(II) chloride; sodium azide; 10% palladium on activated charcoal; hydrogen; ammonium chloride; triethylamine; lithium chloride; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; N,N-dimethyl-formamide; 4: Stille coupling;
DOI:10.1016/j.ejmech.2011.01.014

Reference yield:

: 856866-72-3
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one

: 1293990-11-0
(S)-N-((3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-2-oxo-oxazolidin-5-yl)methyl)-2-hydroxyacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: sodium azide / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

3: 10% palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C

4: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

5: 10% palladium on activated charcoal; hydrogen / 48 h / 20 °C

With sodium azide; 10% palladium on activated charcoal; hydrogen; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.01.014