(+/-)-1-(4-fluorophenyl)-2-(1H-imidazol-1-yl)ethyl 3-(trifluoromethyl)benzoate

Base Information

Chemical Name:(+/-)-1-(4-fluorophenyl)-2-(1H-imidazol-1-yl)ethyl 3-(trifluoromethyl)benzoate
CAS No.:1363792-08-8
Molecular Formula:C₁₉H₁₄F₄N₂O₂
Molecular Weight:378.326
Hs Code.:

Synonyms:(+/-)-1-(4-fluorophenyl)-2-(1H-imidazol-1-yl)ethyl 3-(trifluoromethyl)benzoate

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Chemical Property of (+/-)-1-(4-fluorophenyl)-2-(1H-imidazol-1-yl)ethyl 3-(trifluoromethyl)benzoate

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Technology Process of (+/-)-1-(4-fluorophenyl)-2-(1H-imidazol-1-yl)ethyl 3-(trifluoromethyl)benzoate

There total 3 articles about (+/-)-1-(4-fluorophenyl)-2-(1H-imidazol-1-yl)ethyl 3-(trifluoromethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 2251-65-2
3-(Trifluoromethyl)benzoyl chloride

: 24155-46-2
1-(4-fluorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

: 1363792-08-8
(+/-)-1-(4-fluorophenyl)-2-(1H-imidazol-1-yl)ethyl 3-(trifluoromethyl)benzoate

Guidance literature:: 1-(4-fluorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol; With sodium hydride; In acetonitrile; at 20 ℃; for 2h;

3-(Trifluoromethyl)benzoyl chloride; In acetonitrile; for 2h; Reflux;
DOI:10.1016/j.ejmech.2012.01.034

Reference yield:

: 24155-33-7
1-(4-fluorophenyl)-2-(1H-imidazol-1-yl)ethanone

: 1363792-08-8
(+/-)-1-(4-fluorophenyl)-2-(1H-imidazol-1-yl)ethyl 3-(trifluoromethyl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / methanol

2.1: sodium hydride / acetonitrile / 2 h / 20 °C

2.2: 2 h / Reflux

With sodium tetrahydroborate; sodium hydride; In methanol; acetonitrile;
DOI:10.1016/j.ejmech.2012.01.034

Reference yield:

: 403-29-2
2-bromo-4'-fluoroacetophenone

: 1363792-08-8
(+/-)-1-(4-fluorophenyl)-2-(1H-imidazol-1-yl)ethyl 3-(trifluoromethyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide

2.1: sodium tetrahydroborate / methanol

3.1: sodium hydride / acetonitrile / 2 h / 20 °C

3.2: 2 h / Reflux

With sodium tetrahydroborate; sodium hydride; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2012.01.034