(R)-tert-butyl 2-((2-(2,6-difluoro-4-(methylcarbamoyl)phenyl)-5-methyl-lH-benzo[d]imidazol-l-yl)methyl)morpholine-4-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 2-((2-(2,6-difluoro-4-(methylcarbamoyl)phenyl)-5-methyl-lH-benzo[d]imidazol-l-yl)methyl)morpholine-4-carboxylate
CAS No.:1308849-97-9
Molecular Formula:C₂₆H₃₀F₂N₄O₄
Molecular Weight:500.545
Hs Code.:

Synonyms:(R)-tert-butyl 2-((2-(2,6-difluoro-4-(methylcarbamoyl)phenyl)-5-methyl-lH-benzo[d]imidazol-l-yl)methyl)morpholine-4-carboxylate

Suppliers and Price of (R)-tert-butyl 2-((2-(2,6-difluoro-4-(methylcarbamoyl)phenyl)-5-methyl-lH-benzo[d]imidazol-l-yl)methyl)morpholine-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-tert-butyl 2-((2-(2,6-difluoro-4-(methylcarbamoyl)phenyl)-5-methyl-lH-benzo[d]imidazol-l-yl)methyl)morpholine-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-tert-butyl 2-((2-(2,6-difluoro-4-(methylcarbamoyl)phenyl)-5-methyl-lH-benzo[d]imidazol-l-yl)methyl)morpholine-4-carboxylate

There total 12 articles about (R)-tert-butyl 2-((2-(2,6-difluoro-4-(methylcarbamoyl)phenyl)-5-methyl-lH-benzo[d]imidazol-l-yl)methyl)morpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1308849-85-5
3,5-difluoro-4-formyl-N-methylbenzamide

: 1308849-91-3
(S)-tert-butyl 2-((1,3-dioxoisoindolin-2-yl)methyl)morpholine-4-carboxylate

: 446-11-7
4-fluoro-3-nitrotoluene

: 1308849-97-9
(R)-tert-butyl 2-((2-(2,6-difluoro-4-(methylcarbamoyl)phenyl)-5-methyl-lH-benzo[d]imidazol-l-yl)methyl)morpholine-4-carboxylate

Guidance literature:: (S)-tert-butyl 2-((1,3-dioxoisoindolin-2-yl)methyl)morpholine-4-carboxylate; With ethanolamine; In 2-methyltetrahydrofuran; at 25 - 40 ℃; for 22h; Inert atmosphere;

4-fluoro-3-nitrotoluene; With calcium carbonate; In dimethyl sulfoxide; at 110 ℃; for 20h;

3,5-difluoro-4-formyl-N-methylbenzamide; With sodium dithionite; In ethanol; dimethyl sulfoxide; at 47 - 80 ℃; for 26h;

Reference yield:

: 1308849-96-8
(R)-4-(1-((4-(tert-butoxycarbonyl)morpholin-2-yl)methyl)-5-methyl-1H-benzo[d]imidazol-2-yl)-3,5-difluorobenzoic acid

: 74-89-5
methylamine

: 1308849-97-9
(R)-tert-butyl 2-((2-(2,6-difluoro-4-(methylcarbamoyl)phenyl)-5-methyl-lH-benzo[d]imidazol-l-yl)methyl)morpholine-4-carboxylate

Guidance literature:: (R)-4-(1-((4-(tert-butoxycarbonyl)morpholin-2-yl)methyl)-5-methyl-1H-benzo[d]imidazol-2-yl)-3,5-difluorobenzoic acid; With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In N,N-dimethyl-formamide; for 0.5h; Inert atmosphere;

methylamine; In ethanol; N,N-dimethyl-formamide; for 3h;

Reference yield:

: 135065-76-8
tert-butyl (2S)-2-(hydroxymethyl)morpholine-4-carboxylate

: 1308849-97-9
(R)-tert-butyl 2-((2-(2,6-difluoro-4-(methylcarbamoyl)phenyl)-5-methyl-lH-benzo[d]imidazol-l-yl)methyl)morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

2.1: N,N-dimethyl-formamide / 16 h / 110 - 115 °C

3.1: ethanolamine / 16 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / methanol / 0.5 h / 140 °C / microwave irradiation

5.1: zinc; acetic acid / methanol / 90 h / 20 °C

6.1: acetic acid / methanol / 1.5 h / 20 °C

7.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

7.2: 3 h

With ethanolamine; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; zinc; In methanol; dichloromethane; N,N-dimethyl-formamide;