5-HYDROXY-HOMOPHTHALIC ACID

Base Information

• Chemical Name: 5-HYDROXY-HOMOPHTHALIC ACID
• CAS No.: 67755-25-3
• Molecular Formula: C9H8O5
• Molecular Weight: 196.16
• Mol file: 67755-25-3.mol

Synonyms:2-(CARBOXYMETHYL)-5-HYDROXYBENZOIC ACID;5-HYDROXY-HOMOPHTHALIC ACID

Chemical Property of 5-HYDROXY-HOMOPHTHALIC ACID

Chemical Property:

• PSA: 94.83000
• LogP: 0.71750

Purity/Quality:

98%min ^*data from raw suppliers

2-(carboxymethyl)-5-hydroxybenzoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-HYDROXY-HOMOPHTHALIC ACID

There total 11 articles about 5-HYDROXY-HOMOPHTHALIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.6%

5-amino-2-(carboxymethyl)benzoic acid (22901-69-5) → 2-carboxymethyl-5-hydroxybenzoic acid (67755-25-3)

Guidance literature:

5-amino-2-(carboxymethyl)benzoic acid; With sulfuric acid; sodium nitrite; In water; at 0 - 5 ℃; for 0.5h;

In water; at 100 ℃; for 3h;

DOI:10.1016/j.bmcl.2015.12.014

Reference yield: 50.0%

2-(β,β-dichloroethenyl)-5-hydroxybenzoic acid (586415-12-5) → 2-carboxymethyl-5-hydroxybenzoic acid (67755-25-3)

Guidance literature:

With sulfuric acid; at 20 ℃; for 0.5h;

DOI:10.3390/molecules191220906

Reference yield:

2-(carboxymethyl)-5-nitrobenzoic acid (3898-66-6) → 2-carboxymethyl-5-hydroxybenzoic acid (67755-25-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Raney nickel; methanol / 91938.4 Torr / Hydrogenation

2: aqueous sulfuric acid

With methanol; sulfuric acid; nickel;

DOI:10.1021/jo01182a007

upstream raw materials:

5-amino-2-(carboxymethyl)benzoic acid

2-(β,β-dichloroethenyl)-5-hydroxybenzoic acid

2-(carboxymethyl)-5-nitrobenzoic acid

Homophthalic acid

Downstream raw materials:

5-methoxy-2-methoxycarbonylmethyl-benzoic acid methyl ester

2-(carboxymethyl)-5-methoxybenzoic acid

methyl 5-hydroxy-2-(2-methoxy-2-oxoethyl)benzoate

Refernces

• 1、 Zhao, Qian,Xu, Xi,Xie, Zhouling,Liu, Xiao,You, Qidong,Guo, Qinglong,Zhong, Yi,Li, Zhiyu. "Design, synthesis and biological evaluation of 3-substituted indenoisoquinoline derivatives as topoisomerase I inhibitors". supporting information. p. 1068 - 1072. Retrieved 2016/05/24.
• 2、 -. "2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS". Page/Page column 112-113. . Retrieved 2012/07/13.