2-(4-oxo-3,4-dihydro-2H-chromen-6-yl)ethyl 4-methylbenzenesulfonate

Base Information

Chemical Name:2-(4-oxo-3,4-dihydro-2H-chromen-6-yl)ethyl 4-methylbenzenesulfonate
CAS No.:1176327-37-9
Molecular Formula:C₁₈H₁₈O₅S
Molecular Weight:346.404
Hs Code.:

Synonyms:2-(4-oxo-3,4-dihydro-2H-chromen-6-yl)ethyl 4-methylbenzenesulfonate

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Chemical Property of 2-(4-oxo-3,4-dihydro-2H-chromen-6-yl)ethyl 4-methylbenzenesulfonate

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Technology Process of 2-(4-oxo-3,4-dihydro-2H-chromen-6-yl)ethyl 4-methylbenzenesulfonate

There total 11 articles about 2-(4-oxo-3,4-dihydro-2H-chromen-6-yl)ethyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1361061-39-3
3-[4-(2-{[(4-methylphenyl)sulfonyl]oxy}ethyl)phenoxy]propanoic acid

: 1176327-37-9
2-(4-oxo-3,4-dihydro-2H-chromen-6-yl)ethyl 4-methylbenzenesulfonate

Guidance literature:: With phosphoric acid; trifluoroacetic anhydride; at 0 - 25 ℃; for 1h; Inert atmosphere;
DOI:10.1021/op200357h

Reference yield: 89.0%

: 1176327-36-8
6-(2-hydroxyethyl)-2,3-dihydro-4H-chromen-4-one

: 98-59-9
p-toluenesulfonyl chloride

: 1176327-37-9
2-(4-oxo-3,4-dihydro-2H-chromen-6-yl)ethyl 4-methylbenzenesulfonate

Guidance literature:: With trimethylamine hydrochloride; triethylamine; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.bmc.2018.02.008

Reference yield:

: 14199-15-6
Methyl 4-hydroxyphenylacetate

: 1176327-37-9
2-(4-oxo-3,4-dihydro-2H-chromen-6-yl)ethyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / acetonitrile; water / 3 h / Reflux

2.1: sodium hypochlorite; disodium hydrogenphosphate; potassium dihydrogenphosphate; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile; water / 3 h / 20 - 25 °C

3.1: thionyl chloride / toluene / 3 h / 60 °C

4.1: aluminum (III) chloride / dichloromethane / 2 h / 20 - 25 °C

4.2: 15 °C

5.1: toluene-4-sulfonic acid / methanol / 20 h / 15 - 20 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 30 °C

6.2: 15 °C

6.3: 15 - 25 °C

7.1: triethylamine / trimethylamine hydrochloride / acetonitrile / 5 - 15 °C

With aluminum (III) chloride; sodium hypochlorite; sodium chlorite; disodium hydrogenphosphate; potassium dihydrogenphosphate; lithium aluminium tetrahydride; thionyl chloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium carbonate; triethylamine; trimethylamine hydrochloride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile;