3-(4-acetylphenyl)-4-(1-methyl-1H-indol-3-yl)-N-(2-(pyridin-2-yl)propan-2-yl)butanamide

Base Information

Chemical Name:3-(4-acetylphenyl)-4-(1-methyl-1H-indol-3-yl)-N-(2-(pyridin-2-yl)propan-2-yl)butanamide
CAS No.:1620051-21-9
Molecular Formula:C₂₉H₃₁N₃O₂
Molecular Weight:453.584
Hs Code.:

Synonyms:3-(4-acetylphenyl)-4-(1-methyl-1H-indol-3-yl)-N-(2-(pyridin-2-yl)propan-2-yl)butanamide

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Chemical Property of 3-(4-acetylphenyl)-4-(1-methyl-1H-indol-3-yl)-N-(2-(pyridin-2-yl)propan-2-yl)butanamide

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Technology Process of 3-(4-acetylphenyl)-4-(1-methyl-1H-indol-3-yl)-N-(2-(pyridin-2-yl)propan-2-yl)butanamide

There total 4 articles about 3-(4-acetylphenyl)-4-(1-methyl-1H-indol-3-yl)-N-(2-(pyridin-2-yl)propan-2-yl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 13329-40-3
4-Iodoacetophenone

: 1620050-87-4
4-(1-methyl-1H-indol-3-yl)-N-(2-(pyridin-2-yl)propan-2-yl)butanamide

: 1620051-21-9
3-(4-acetylphenyl)-4-(1-methyl-1H-indol-3-yl)-N-(2-(pyridin-2-yl)propan-2-yl)butanamide

Guidance literature:: With silver(I) acetate; palladium diacetate; In tert-butyl alcohol; at 100 ℃; for 24h; Schlenk technique; Inert atmosphere;
DOI:10.1039/c4cc03615h

Reference yield: 32.0%

: 1620050-87-4
4-(1-methyl-1H-indol-3-yl)-N-(2-(pyridin-2-yl)propan-2-yl)butanamide

: 99-90-1
para-bromoacetophenone

: 1620051-21-9
3-(4-acetylphenyl)-4-(1-methyl-1H-indol-3-yl)-N-(2-(pyridin-2-yl)propan-2-yl)butanamide

Guidance literature:: With palladium diacetate; potassium carbonate; Trimethylacetic acid; In tert-butyl alcohol; at 120 ℃; for 24h; Schlenk technique; Inert atmosphere;
DOI:10.1039/c4cc03615h

Reference yield:

: 52568-28-2
2-(pyridin-2-yl)isopropyl amine

: 1620051-21-9
3-(4-acetylphenyl)-4-(1-methyl-1H-indol-3-yl)-N-(2-(pyridin-2-yl)propan-2-yl)butanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 0.5 h / Cooling with ice

1.2: Cooling with ice

2.1: palladium diacetate; silver(I) acetate / tert-butyl alcohol / 24 h / 100 °C / Schlenk technique; Inert atmosphere

With 4-methyl-morpholine; silver(I) acetate; palladium diacetate; isobutyl chloroformate; In dichloromethane; tert-butyl alcohol;
DOI:10.1039/c4cc03615h