(S)-2-methyl-propane-2-sulfinic acid [(S)-1-(2,4-difluoro-3-phenoxy-phenyl)-propyl]-amide

Base Information

Chemical Name:(S)-2-methyl-propane-2-sulfinic acid [(S)-1-(2,4-difluoro-3-phenoxy-phenyl)-propyl]-amide
CAS No.:1434722-30-1
Molecular Formula:C₁₉H₂₃F₂NO₂S
Molecular Weight:367.46
Hs Code.:

Synonyms:(S)-2-methyl-propane-2-sulfinic acid [(S)-1-(2,4-difluoro-3-phenoxy-phenyl)-propyl]-amide

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Chemical Property of (S)-2-methyl-propane-2-sulfinic acid [(S)-1-(2,4-difluoro-3-phenoxy-phenyl)-propyl]-amide

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Technology Process of (S)-2-methyl-propane-2-sulfinic acid [(S)-1-(2,4-difluoro-3-phenoxy-phenyl)-propyl]-amide

There total 8 articles about (S)-2-methyl-propane-2-sulfinic acid [(S)-1-(2,4-difluoro-3-phenoxy-phenyl)-propyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1434722-27-6
(S)-2-methyl-propane-2-sulfinic acid (E)-1-(2,4-difluoro-3-phenoxy-phenyl)-methylideneamide

: 925-90-6
ethylmagnesium bromide

: 1434722-30-1
(S)-2-methyl-propane-2-sulfinic acid [(S)-1-(2,4-difluoro-3-phenoxy-phenyl)-propyl]-amide

: 1434723-97-3
C₁₉H₂₃F₂NO₂S

Guidance literature:: In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

Reference yield:

: 261763-46-6
3-methyl-2,6-difluorophenol

: 1434722-30-1
(S)-2-methyl-propane-2-sulfinic acid [(S)-1-(2,4-difluoro-3-phenoxy-phenyl)-propyl]-amide

: 1434723-97-3
C₁₉H₂₃F₂NO₂S

Guidance literature:: Multi-step reaction with 5 steps

1: cesium fluoride / acetonitrile / Inert atmosphere

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 80 - 90 °C / Inert atmosphere

3: sodium hydrogencarbonate; dimethyl sulfoxide / 80 °C / Inert atmosphere

4: titanium(IV) tetraethanolate / dichloromethane / Inert atmosphere

5: tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

With titanium(IV) tetraethanolate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydrogencarbonate; dimethyl sulfoxide; cesium fluoride; In tetrahydrofuran; tetrachloromethane; dichloromethane; acetonitrile;

Reference yield:

: 98-80-6
phenylboronic acid

: 1434722-30-1
(S)-2-methyl-propane-2-sulfinic acid [(S)-1-(2,4-difluoro-3-phenoxy-phenyl)-propyl]-amide

: 1434723-97-3
C₁₉H₂₃F₂NO₂S

Guidance literature:: Multi-step reaction with 3 steps

1: copper diacetate; pyridine; pyridine N-oxide / dichloromethane / 48 h / 20 °C / Molecular sieve

2: titanium(IV) tetraethanolate / dichloromethane / Inert atmosphere

3: tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

With pyridine; pyridine N-oxide; titanium(IV) tetraethanolate; copper diacetate; In tetrahydrofuran; dichloromethane;