1-(4-chlorobenzyl)-4-[2-hydroxy-3-(4-hydroxy-3-nitro-8-n-propylcoumarin-7-yloxy)propyl]piperazine

Base Information

Chemical Name:1-(4-chlorobenzyl)-4-[2-hydroxy-3-(4-hydroxy-3-nitro-8-n-propylcoumarin-7-yloxy)propyl]piperazine
CAS No.:75590-46-4
Molecular Formula:C₂₆H₃₀ClN₃O₇
Molecular Weight:531.993
Hs Code.:

Synonyms:1-(4-chlorobenzyl)-4-[2-hydroxy-3-(4-hydroxy-3-nitro-8-n-propylcoumarin-7-yloxy)propyl]piperazine

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Chemical Property of 1-(4-chlorobenzyl)-4-[2-hydroxy-3-(4-hydroxy-3-nitro-8-n-propylcoumarin-7-yloxy)propyl]piperazine

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Technology Process of 1-(4-chlorobenzyl)-4-[2-hydroxy-3-(4-hydroxy-3-nitro-8-n-propylcoumarin-7-yloxy)propyl]piperazine

There total 6 articles about 1-(4-chlorobenzyl)-4-[2-hydroxy-3-(4-hydroxy-3-nitro-8-n-propylcoumarin-7-yloxy)propyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 75590-45-3
1-(4-chlorobenzyl)-4-[2-hydroxy-3-(4-hydroxy-8-n-propylcoumarin-7-yloxy)propyl]piperazine

: 75590-46-4
1-(4-chlorobenzyl)-4-[2-hydroxy-3-(4-hydroxy-3-nitro-8-n-propylcoumarin-7-yloxy)propyl]piperazine

Guidance literature:: With nitric acid; In chloroform; at 0 ℃; for 1h;
DOI:10.1021/jm00377a013

Reference yield:

: 23145-88-2
1-[(4-chlorophenyl)methyl]piperazine

: 75590-46-4
1-(4-chlorobenzyl)-4-[2-hydroxy-3-(4-hydroxy-3-nitro-8-n-propylcoumarin-7-yloxy)propyl]piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: 52 percent / ethanol / 1.5 h / Heating

2: 80 percent / H₂ / 10percent Pd/C / dimethylformamide / 760 Torr

3: 89 percent / HNO₃ / CHCl₃ / 1 h / 0 °C

With hydrogen; nitric acid; palladium on activated charcoal; In ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00377a013

Reference yield:

: 55037-87-1
ethyl 4-(4-chlorobenzyl)piperazine-1-carboxylate

: 75590-46-4
1-(4-chlorobenzyl)-4-[2-hydroxy-3-(4-hydroxy-3-nitro-8-n-propylcoumarin-7-yloxy)propyl]piperazine

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / 20percent w/v aq. NaOH / 2-ethoxy-ethanol / 18 h / Heating

2: 52 percent / ethanol / 1.5 h / Heating

3: 80 percent / H₂ / 10percent Pd/C / dimethylformamide / 760 Torr

4: 89 percent / HNO₃ / CHCl₃ / 1 h / 0 °C

With sodium hydroxide; hydrogen; nitric acid; palladium on activated charcoal; In 2-ethoxy-ethanol; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00377a013