(S)-tert-butyl 3-(2,5-dichloro-4-((2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)pyrrolidin-1-yl)methyl)phenyl)propanoate

Base Information

Chemical Name:(S)-tert-butyl 3-(2,5-dichloro-4-((2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)pyrrolidin-1-yl)methyl)phenyl)propanoate
CAS No.:1445985-08-9
Molecular Formula:C₃₀H₃₇Cl₂N₃O₃
Molecular Weight:558.548
Hs Code.:

Synonyms:(S)-tert-butyl 3-(2,5-dichloro-4-((2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)pyrrolidin-1-yl)methyl)phenyl)propanoate

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Chemical Property of (S)-tert-butyl 3-(2,5-dichloro-4-((2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)pyrrolidin-1-yl)methyl)phenyl)propanoate

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Technology Process of (S)-tert-butyl 3-(2,5-dichloro-4-((2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)pyrrolidin-1-yl)methyl)phenyl)propanoate

There total 16 articles about (S)-tert-butyl 3-(2,5-dichloro-4-((2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)pyrrolidin-1-yl)methyl)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1445985-07-8
tert-butyl 3-[4-(bromomethyl)-2,5-dichlorophenyl]-propanoate

: 1445984-85-9
(S)-(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(pyrrolidin-2-yl)methanone

: 1445985-08-9
(S)-tert-butyl 3-(2,5-dichloro-4-((2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)pyrrolidin-1-yl)methyl)phenyl)propanoate

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃;

Reference yield:

: 1124-05-6
1,4-dichloro-2,5-dimethylbenzene

: 1445985-08-9
(S)-tert-butyl 3-(2,5-dichloro-4-((2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)pyrrolidin-1-yl)methyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid; acetic anhydride; sulfuric acid; chromium(VI) oxide / 6 h / 0 - 20 °C

2: sodium hydroxide / dichloromethane; water / 1 h / 0 °C

3: sodium tetrahydroborate / methanol / 1 h / 20 °C

4: hydrogen; rhodium contaminated with carbon / ethyl acetate / 20 °C

5: triphenylphosphine; N-Bromosuccinimide / dichloromethane; tetrahydrofuran / 2 h / 0 °C

6: potassium carbonate / acetonitrile / 20 °C

With chromium(VI) oxide; sodium tetrahydroborate; N-Bromosuccinimide; sulfuric acid; rhodium contaminated with carbon; hydrogen; acetic anhydride; potassium carbonate; acetic acid; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; acetonitrile;
DOI:10.1021/acs.jmedchem.8b00308

Reference yield:

: 1445985-04-5
tert-butyl 3-(2,5-dichloro-4-formylphenyl)acrylate

: 1445985-08-9
(S)-tert-butyl 3-(2,5-dichloro-4-((2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)pyrrolidin-1-yl)methyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / methanol / 1 h / 20 °C

2: hydrogen; rhodium contaminated with carbon / ethyl acetate / 20 °C

3: triphenylphosphine; N-Bromosuccinimide / dichloromethane; tetrahydrofuran / 2 h / 0 °C

4: potassium carbonate / acetonitrile / 20 °C

With sodium tetrahydroborate; N-Bromosuccinimide; rhodium contaminated with carbon; hydrogen; potassium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1021/acs.jmedchem.8b00308